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ZNF676 zinc finger protein 676 [ Homo sapiens (human) ]

Gene ID: 163223, updated on 23-Nov-2023

Summary

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Official Symbol
ZNF676provided by HGNC
Official Full Name
zinc finger protein 676provided by HGNC
Primary source
HGNC:HGNC:20429
See related
Ensembl:ENSG00000196109 AllianceGenome:HGNC:20429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 3.0), thyroid (RPKM 2.0) and 14 other tissues See more
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Genomic context

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See ZNF676 in Genome Data Viewer
Location:
19p12
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (22179089..22260304, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (22317323..22398923, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (22361891..22379753, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:22322832-22323332 Neighboring gene metadherin pseudogene 5 Neighboring gene vomeronasal 1 receptor 85 pseudogene Neighboring gene BCL2 interacting protein 3 pseudogene 30 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:22399096-22399311 Neighboring gene zinc finger protein 729 Neighboring gene BCL2 interacting protein 3 pseudogene 31 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:22504465-22505169 Neighboring gene uncharacterized LOC105372330

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population. Jiang T, et al. Fertil Steril, 2017 Dec. PMID 29202958
  2. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Mangino M, et al. Hum Mol Genet, 2012 Dec 15. PMID 23001564, Free PMC Article
  3. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Levy D, et al. Proc Natl Acad Sci U S A, 2010 May 18. PMID 20421499, Free PMC Article
  4. Identification of DeltaNp63alpha protein interactions by mass spectrometry. Amoresano A, et al. J Proteome Res, 2010 Apr 5. PMID 20085233
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptome wide association study results identified two novel genes as statistically significantly associated with nonobstructive azoospermia susceptibility: PILRA and ZNF676.
    Title: Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population.
  2. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.
    Title: Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology.
EBI GWAS Catalog
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 676

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001411.3 → NP_001001411.2  zinc finger protein 676

    See identical proteins and their annotated locations for NP_001001411.2

    Status: VALIDATED

    Source sequence(s)
    AC073539, AK097798, BX281304
    Consensus CDS
    CCDS42539.1
    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3
    Related
    ENSP00000380310.1, ENST00000397121.3
    Conserved Domains (5) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:195 → 580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:114 → 135
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:547 → 572
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    22179089..22260304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438360.1 → XP_047294316.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  2. XM_047438355.1 → XP_047294311.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  3. XM_047438358.1 → XP_047294314.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  4. XM_047438357.1 → XP_047294313.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  5. XM_047438354.1 → XP_047294310.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  6. XM_047438353.1 → XP_047294309.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  7. XM_047438359.1 → XP_047294315.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  8. XM_047438356.1 → XP_047294312.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  9. XM_047438361.1 → XP_047294317.1  zinc finger protein 676 isoform X3

  10. XM_047438352.1 → XP_047294308.1  zinc finger protein 676 isoform X1

    UniProtKB/TrEMBL
    A0A3B3ITU2
    Related
    ENSP00000497897.1, ENST00000650058.1

  11. XM_047438362.1 → XP_047294318.1  zinc finger protein 676 isoform X3

RNA

  1. XR_007066663.1 RNA Sequence

  2. XR_007066662.1 RNA Sequence

  3. XR_007066660.1 RNA Sequence

  4. XR_007066659.1 RNA Sequence

  5. XR_007066658.1 RNA Sequence

  6. XR_007066657.1 RNA Sequence

  7. XR_007066656.1 RNA Sequence

  8. XR_007066654.1 RNA Sequence

  9. XR_007066655.1 RNA Sequence

  10. XR_007066661.1 RNA Sequence

  11. XR_002958433.2 RNA Sequence

  12. XR_001754085.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315965.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    40665..129785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329601.1 → XP_054185576.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  2. XM_054329602.1 → XP_054185577.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  3. XM_054329604.1 → XP_054185579.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  4. XM_054329605.1 → XP_054185580.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  5. XM_054329603.1 → XP_054185578.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  6. XM_054329607.1 → XP_054185582.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  7. XM_054329606.1 → XP_054185581.1  zinc finger protein 676 isoform X2

    UniProtKB/Swiss-Prot
    A8MVX5, Q8N7Q3

  8. XM_054329600.1 → XP_054185575.1  zinc finger protein 676 isoform X1

    UniProtKB/TrEMBL
    A0A3B3ITU2

  9. XM_054329608.1 → XP_054185583.1  zinc finger protein 676 isoform X3

  10. XM_054329610.1 → XP_054185585.1  zinc finger protein 676 isoform X4

  11. XM_054329609.1 → XP_054185584.1  zinc finger protein 676 isoform X3

RNA

  1. XR_001756497.2 RNA Sequence

  2. XR_001756496.3 RNA Sequence

  3. XR_007068730.1 RNA Sequence

  4. XR_001756494.2 RNA Sequence

  5. XR_007068727.1 RNA Sequence

  6. XR_007068728.1 RNA Sequence

  7. XR_007068729.1 RNA Sequence

  8. XR_001756498.2 RNA Sequence

  9. XR_001756499.2 RNA Sequence

  10. XR_001756503.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    22317323..22398923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320102.1 → XP_054176077.1  zinc finger protein 676 isoform X2

  2. XM_054320096.1 → XP_054176071.1  zinc finger protein 676 isoform X2

  3. XM_054320099.1 → XP_054176074.1  zinc finger protein 676 isoform X2

  4. XM_054320098.1 → XP_054176073.1  zinc finger protein 676 isoform X2

  5. XM_054320095.1 → XP_054176070.1  zinc finger protein 676 isoform X2

  6. XM_054320094.1 → XP_054176069.1  zinc finger protein 676 isoform X2

  7. XM_054320101.1 → XP_054176076.1  zinc finger protein 676 isoform X2

  8. XM_054320100.1 → XP_054176075.1  zinc finger protein 676 isoform X2

  9. XM_054320097.1 → XP_054176072.1  zinc finger protein 676 isoform X2

  10. XM_054320105.1 → XP_054176080.1  zinc finger protein 676 isoform X5

  11. XM_054320103.1 → XP_054176078.1  zinc finger protein 676 isoform X3

  12. XM_054320093.1 → XP_054176068.1  zinc finger protein 676 isoform X1

  13. XM_054320104.1 → XP_054176079.1  zinc finger protein 676 isoform X3

RNA

  1. XR_007089028.1 RNA Sequence

  2. XR_007089027.1 RNA Sequence

  3. XR_007089025.1 RNA Sequence

  4. XR_007089024.1 RNA Sequence

  5. XR_007089023.1 RNA Sequence

  6. XR_007089022.1 RNA Sequence

  7. XR_007089021.1 RNA Sequence

  8. XR_007089019.1 RNA Sequence

  9. XR_007089020.1 RNA Sequence

  10. XR_007089026.1 RNA Sequence

  11. XR_007089030.1 RNA Sequence

  12. XR_007089029.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N7Q3.2 GenPept UniProtKB/Swiss-Prot:Q8N7Q3

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