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Inpp1 inositol polyphosphate-1-phosphatase [ Mus musculus (house mouse) ]

Gene ID: 16329, updated on 11-Apr-2024

Summary

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Official Symbol
Inpp1provided by MGI
Official Full Name
inositol polyphosphate-1-phosphataseprovided by MGI
Primary source
MGI:MGI:104848
See related
Ensembl:ENSMUSG00000026102 AllianceGenome:MGI:104848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2300002C06Rik
Summary
Predicted to enable inositol-1,4-bisphosphate 1-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation. Is expressed in several structures, including nervous system; sensory organ; and skeleton. Orthologous to human INPP1 (inositol polyphosphate-1-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 6.4), CNS E18 (RPKM 4.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C1.1; 1 26.99 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52824584..52856847, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52785425..52817688, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5753 Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_00904 Neighboring gene STARR-positive B cell enhancer ABC_E3274 Neighboring gene STARR-positive B cell enhancer ABC_E1543 Neighboring gene STARR-positive B cell enhancer ABC_E3275 Neighboring gene 3-hydroxyisobutyryl-Coenzyme A hydrolase Neighboring gene STARR-seq mESC enhancer starr_00905 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene RIKEN cDNA 1700019D03 gene Neighboring gene STARR-seq mESC enhancer starr_00906 Neighboring gene STARR-seq mESC enhancer starr_00907

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor. Woodcock EA, et al. J Biol Chem, 2002 Jun 21. PMID 11932254
  2. The role of phosphatases in inositol signaling reactions. Majerus PW, et al. J Biol Chem, 1999 Apr 16. PMID 10196133
  3. Identification and chromosomal mapping of the mouse inositol polyphosphate 1-phosphatase gene. Okabe I, et al. Genomics, 1995 Nov 20. PMID 8586440
  4. Synaptic defects and compensatory regulation of inositol metabolism in inositol polyphosphate 1-phosphatase mutants. Acharya JK, et al. Neuron, 1998 Jun. PMID 9655509
  5. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Varfolomeev EE, et al. Immunity, 1998 Aug. PMID 9729047

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.
    Title: Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,4-bisphosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inositol polyphosphate 1-phosphatase
Names
IPP
IPPase
NP_032410.2
XP_011236743.1
XP_011236744.1
XP_036018134.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008384.2 → NP_032410.2  inositol polyphosphate 1-phosphatase

    See identical proteins and their annotated locations for NP_032410.2

    Status: VALIDATED

    Source sequence(s)
    AK078382, BY700907, BY713450
    Consensus CDS
    CCDS14947.1
    UniProtKB/Swiss-Prot
    P49442, Q8R3L1
    Related
    ENSMUSP00000027271.3, ENSMUST00000027271.9
    Conserved Domains (1) summary
    cd01640
    Location:4 → 384
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    52824584..52856847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162241.1 → XP_036018134.1  inositol polyphosphate 1-phosphatase isoform X1

    UniProtKB/Swiss-Prot
    P49442, Q8R3L1
    Conserved Domains (1) summary
    cd01640
    Location:4 → 384
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

  2. XM_011238441.3 → XP_011236743.1  inositol polyphosphate 1-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_011236743.1

    UniProtKB/Swiss-Prot
    P49442, Q8R3L1
    Conserved Domains (1) summary
    cd01640
    Location:4 → 384
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

  3. XM_011238442.4 → XP_011236744.1  inositol polyphosphate 1-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_011236744.1

    UniProtKB/Swiss-Prot
    P49442, Q8R3L1
    Conserved Domains (1) summary
    cd01640
    Location:4 → 384
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49442.2 GenPept UniProtKB/Swiss-Prot:P49442

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