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Itgae integrin alpha E, epithelial-associated [ Mus musculus (house mouse) ]

Gene ID: 16407, updated on 26-Jul-2021

Summary

Official Symbol
Itgaeprovided by MGI
Official Full Name
integrin alpha E, epithelial-associatedprovided by MGI
Primary source
MGI:MGI:1298377
See related
Ensembl:ENSMUSG00000005947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
alph; CD103; aM290; alpha-E1; A530055J10; alpha-M290
Expression
Biased expression in thymus adult (RPKM 6.0), testis adult (RPKM 5.9) and 10 other tissues See more
Orthologs
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Genomic context

See Itgae in Genome Data Viewer
Location:
11 B4; 11 45.22 cM
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72981335..73038425)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73090505..73147449)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (72904097..72960951)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1, alpha Neighboring gene nuclear cap binding subunit 3 Neighboring gene histone H3 associated protein kinase Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 5 Neighboring gene ER membrane protein complex subunit 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC183601

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
integrin alpha-E
Names
integrin alpha M290

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361245.1NP_001348174.1  integrin alpha-E isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL670399
    Conserved Domains (3) summary
    smart00191
    Location:565624
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:195370
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:667938
    Integrin_alpha2; Integrin alpha
  2. NM_008399.3NP_032425.2  integrin alpha-E isoform 1 precursor

    See identical proteins and their annotated locations for NP_032425.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK040983, AL670399, AV204610, BF453582, CF983010
    Consensus CDS
    CCDS24995.1
    UniProtKB/Swiss-Prot
    Q60677
    UniProtKB/TrEMBL
    Q8BS01
    Related
    ENSMUSP00000006101.4, ENSMUST00000006101.4
    Conserved Domains (3) summary
    smart00191
    Location:566625
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:196371
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:668939
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72981335..73038425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156348.1XP_036012241.1  integrin alpha-E isoform X1

    Conserved Domains (3) summary
    smart00191
    Location:566624
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:196371
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:667938
    Integrin_alpha2; Integrin alpha

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172944.2: Suppressed sequence

    Description
    NM_172944.2: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
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