Itgav integrin alpha V [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgavprovided by MGI
Official Full Name: integrin alpha Vprovided by MGI
Primary source: MGI:MGI:96608
See related: Ensembl:ENSMUSG00000027087 AllianceGenome:MGI:96608
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik
Summary: This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]
Expression: Ubiquitous expression in placenta adult (RPKM 13.0), ovary adult (RPKM 12.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 D; 2 49.33 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (83554796..83637261)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (83722303..83806917)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrin alphaV mediated activation of myofibroblast via mechanoparacrine of transforming growth factor beta1 in promoting fibrous scar formation after myocardial infarction.
Title: Integrin αV mediated activation of myofibroblast via mechanoparacrine of transforming growth factor β1 in promoting fibrous scar formation after myocardial infarction.
Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating Itgav expression.
Title: Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating Itgav expression.
Milk osteopontin promotes intestinal development by up-regulating the expression of integrin alphavbeta3 and CD44.
Title: Milk osteopontin promotes intestinal development by up-regulating the expression of integrin αvβ3 and CD44.
Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin alphaV/beta5 in Parkinson's Disease.
Title: Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson's Disease.
alphaVbeta3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells.
Title: αVβ3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells.
Integrin alphavbeta8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Title: Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Regulatory T cells promote cancer immune-escape through integrin alphavbeta8-mediated TGF-beta activation.
Title: Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.
Autoregulation of insulin receptor signaling through MFGE8 and the alphavbeta5 integrin.
Title: Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.
alphaV Integrin Expression and Localization in Male Germ Cells.
Title: αV Integrin Expression and Localization in Male Germ Cells.
Discovery of a new class of integrin antibodies for fibrosis.
Title: Discovery of a new class of integrin antibodies for fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (159)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itgav (e-PCR), detects polymorphism
- UniSTS:532239

U14135 (e-PCR)
- UniSTS:163288

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to C-X3-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix protein binding	ISO Inferred from Sequence Orthology more info
contributes_to fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
contributes_to insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to neuregulin binding	ISO Inferred from Sequence Orthology more info
contributes_to opsonin binding	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	ISO Inferred from Sequence Orthology more info
contributes_to protein kinase C binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell activation	TAS Traceable Author Statement more info	PubMed
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in apolipoprotein A-I-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic cell clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic cell clearance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in detection of molecule of bacterial origin	TAS Traceable Author Statement more info	PubMed
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	TAS Traceable Author Statement more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
involved_in fertilization	NAS Non-traceable Author Statement more info	PubMed
involved_in focal adhesion assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in gonad morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of entry of bacterium into host cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of low-density lipoprotein receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone resorption	TAS Traceable Author Statement more info	PubMed
involved_in regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of phagocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in release of sequestered calcium ion into cytosol	TAS Traceable Author Statement more info	PubMed
involved_in response to nitric oxide	TAS Traceable Author Statement more info	PubMed
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in trophoblast giant cell differentiation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of alphav-beta3 integrin-HMGB1 complex	ISO Inferred from Sequence Orthology more info
part_of alphav-beta3 integrin-IGF-1-IGF1R complex	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info	PubMed
part_of integrin alphav-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta3 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta3 complex	TAS Traceable Author Statement more info	PubMed
part_of integrin alphav-beta5 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alphav-beta5 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta6 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alphav-beta6 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta8 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	ISO Inferred from Sequence Orthology more info
located_in lamellipodium membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin alpha-V

Names: alpha v integrin; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398691.1 → NP_001385620.1 integrin alpha-V isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL772301

Conserved Domains (4) summary

smart00191
Location:366 → 420

Int_alpha; Integrin alpha (beta-propellor repeats)

sd00039
Location:125 → 182

7WD40; WD40 repeat [structural motif]

pfam08441
Location:466 → 909

Integrin_alpha2; Integrin alpha

pfam13517
Location:220 → 270

VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
NM_008402.4 → NP_032428.2 integrin alpha-V isoform 1 precursor

See identical proteins and their annotated locations for NP_032428.2

Status: REVIEWED

Source sequence(s)

AL772301

Consensus CDS

CCDS16181.1

UniProtKB/Swiss-Prot

A2AKI6, P43406

UniProtKB/TrEMBL

A0A0F7IQ06

Related

ENSMUSP00000028499.5, ENSMUST00000028499.11

Conserved Domains (3) summary

smart00191
Location:367 → 421

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:467 → 910

Integrin_alpha2; Integrin alpha

sd00039
Location:126 → 183

7WD40; WD40 repeat [structural motif]