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Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 [ Mus musculus (house mouse) ]

Gene ID: 16485, updated on 6-May-2021

Summary

Official Symbol
Kcna1provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 1provided by MGI
Primary source
MGI:MGI:96654
See related
Ensembl:ENSMUSG00000047976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sh; Kv1.; MBK1; Mk-1; Shak; mcep; Kv1.1; mceph; Kca1-1; AI840627
Expression
Biased expression in cerebellum adult (RPKM 30.6), cortex adult (RPKM 12.5) and 1 other tissue See more
Orthologs
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Genomic context

See Kcna1 in Genome Data Viewer
Location:
6 F3; 6 61.57 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126613426..126622764, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126636463..126645801, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (126586481..126595819, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33449 Neighboring gene predicted gene, 33496 Neighboring gene potassium voltage-gated channel, shaker-related, subfamily, member 6 Neighboring gene predicted gene, 33581 Neighboring gene predicted gene, 20190

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124402

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to magnesium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of touch IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in magnesium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuromuscular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuromuscular process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuronal signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within startle response ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in juxtaparanode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in juxtaparanode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in paranode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in paranode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in paranode region of axon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 1
Names
MKI
brain potassium channel protein-1
megencephaly
voltage-gated potassium channel subunit Kv1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010595.3NP_034725.3  potassium voltage-gated channel subfamily A member 1

    See identical proteins and their annotated locations for NP_034725.3

    Status: VALIDATED

    Source sequence(s)
    AC079438
    Consensus CDS
    CCDS20555.1
    UniProtKB/Swiss-Prot
    P16388
    Related
    ENSMUSP00000055225.4, ENSMUST00000055168.5
    Conserved Domains (2) summary
    cl38908
    Location:37163
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:166418
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    126613426..126622764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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