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Kcna6 potassium voltage-gated channel, shaker-related, subfamily, member 6 [ Mus musculus (house mouse) ]

Gene ID: 16494, updated on 23-Jun-2021

Summary

Official Symbol
Kcna6provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related, subfamily, member 6provided by MGI
Primary source
MGI:MGI:96663
See related
Ensembl:ENSMUSG00000038077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kv1.; Kv1.6; MK1.6
Expression
Biased expression in cerebellum adult (RPKM 9.9), cortex adult (RPKM 8.5) and 7 other tissues See more
Orthologs
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Genomic context

See Kcna6 in Genome Data Viewer
Location:
6 F3; 6 61.72 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126685291..126717797, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126708328..126740834, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (126658347..126690692, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33496 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 1 Neighboring gene predicted gene, 33581 Neighboring gene predicted gene, 20190 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 6
Names
voltage-gated potassium channel subunit Kv1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013568.6NP_038596.1  potassium voltage-gated channel subfamily A member 6

    See identical proteins and their annotated locations for NP_038596.1

    Status: VALIDATED

    Source sequence(s)
    AC124756, BC048782, BC054804, BE948246
    Consensus CDS
    CCDS20556.1
    UniProtKB/Swiss-Prot
    Q61923
    Related
    ENSMUSP00000139481.2, ENSMUST00000185333.2
    Conserved Domains (2) summary
    cd18407
    Location:41170
    BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)
    pfam00520
    Location:258468
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    126685291..126717797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241228.3XP_011239530.1  potassium voltage-gated channel subfamily A member 6 isoform X1

    See identical proteins and their annotated locations for XP_011239530.1

    UniProtKB/Swiss-Prot
    Q61923
    Related
    ENSMUSP00000107861.2, ENSMUST00000112242.2
    Conserved Domains (2) summary
    cd18407
    Location:41170
    BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)
    pfam00520
    Location:258468
    Ion_trans; Ion transport protein
  2. XM_006505639.4XP_006505702.1  potassium voltage-gated channel subfamily A member 6 isoform X1

    See identical proteins and their annotated locations for XP_006505702.1

    UniProtKB/Swiss-Prot
    Q61923
    Conserved Domains (2) summary
    cd18407
    Location:41170
    BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)
    pfam00520
    Location:258468
    Ion_trans; Ion transport protein
  3. XM_006505638.4XP_006505701.1  potassium voltage-gated channel subfamily A member 6 isoform X1

    See identical proteins and their annotated locations for XP_006505701.1

    UniProtKB/Swiss-Prot
    Q61923
    Conserved Domains (2) summary
    cd18407
    Location:41170
    BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)
    pfam00520
    Location:258468
    Ion_trans; Ion transport protein
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