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Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 [ Mus musculus (house mouse) ]

Gene ID: 16498, updated on 23-Jun-2021

Summary

Official Symbol
Kcnab2provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, beta member 2provided by MGI
Primary source
MGI:MGI:109239
See related
Ensembl:ENSMUSG00000028931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F5; I2r; Kcnb; I2rf5; Kcnb3; kv-beta-2
Expression
Biased expression in cortex adult (RPKM 40.8), frontal lobe adult (RPKM 32.0) and 9 other tissues See more
Orthologs
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Genomic context

See Kcnab2 in Genome Data Viewer
Location:
4 E2; 4 83.08 cM
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152475201..152562006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152390744..152477549, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (151764853..151851588, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430083M05 gene Neighboring gene ribosomal protein L22 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene predicted gene 16333 Neighboring gene nephronophthisis 4 (juvenile) homolog (human) Neighboring gene predicted gene, 30734 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-threo-aldose 1-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables aldo-keto reductase (NADP) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aldo-keto reductase (NADP) activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in juxtaparanode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in juxtaparanode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in pinceau fiber ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
voltage-gated potassium channel subunit beta-2
Names
K(+) channel subunit beta-2
neuroimmune protein F5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252654.2NP_001239583.1  voltage-gated potassium channel subunit beta-2 isoform 2

    See identical proteins and their annotated locations for NP_001239583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in coding region, compared to variant 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AI835117, AK143166, AL611985, CX224114
    Consensus CDS
    CCDS57316.1
    UniProtKB/TrEMBL
    Q3UPV6
    Related
    ENSMUSP00000030768.3, ENSMUST00000030768.10
    Conserved Domains (1) summary
    cd19141
    Location:25333
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  2. NM_001252655.2NP_001239584.1  voltage-gated potassium channel subunit beta-2 isoform 2

    See identical proteins and their annotated locations for NP_001239584.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region, compared to variant 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AI835117, AK143166, AL611985, BY232563, CK627448, CV784053, CX224114, CX768025
    Consensus CDS
    CCDS57316.1
    UniProtKB/TrEMBL
    Q3UPV6
    Related
    ENSMUSP00000124156.3, ENSMUST00000159840.8
    Conserved Domains (1) summary
    cd19141
    Location:25333
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  3. NM_001252656.2NP_001239585.1  voltage-gated potassium channel subunit beta-2 isoform 1

    See identical proteins and their annotated locations for NP_001239585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2 and 5 encode the same isoform (1).
    Source sequence(s)
    AI835117, AK143166, AK152613, AL611985, CX224114
    Consensus CDS
    CCDS19000.1
    UniProtKB/Swiss-Prot
    P62482
    Related
    ENSMUSP00000101273.3, ENSMUST00000105648.10
    Conserved Domains (1) summary
    cd19141
    Location:38347
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  4. NM_001355172.1NP_001342101.1  voltage-gated potassium channel subunit beta-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
    Source sequence(s)
    AI835117, AK143166, AL611985, CK627448, CV784053, CX224114, CX768025, DN173203
    Consensus CDS
    CCDS19000.1
    Conserved Domains (1) summary
    cd19141
    Location:38347
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  5. NM_001355173.1NP_001342102.1  voltage-gated potassium channel subunit beta-2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AI835117, AK143166, AL611985, BY198829, CK627448, CV784053, CX224114, CX768025, DN173203
    Related
    ENSMUSP00000158843.2, ENSMUST00000238738.2
    Conserved Domains (1) summary
    cd19141
    Location:38363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  6. NM_010598.4NP_034728.2  voltage-gated potassium channel subunit beta-2 isoform 1

    See identical proteins and their annotated locations for NP_034728.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
    Source sequence(s)
    AI835117, AK143166, AL611985, BY198829, CK627448, CV784053, CX224114, CX768025, DN173203
    Consensus CDS
    CCDS19000.1
    UniProtKB/Swiss-Prot
    P62482
    Related
    ENSMUSP00000125058.2, ENSMUST00000160884.9
    Conserved Domains (1) summary
    cd19141
    Location:38347
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152475201..152562006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253266.1XP_030109126.1  voltage-gated potassium channel subunit beta-2 isoform X5

    Conserved Domains (1) summary
    cd19141
    Location:38347
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  2. XM_011250199.3XP_011248501.1  voltage-gated potassium channel subunit beta-2 isoform X3

    See identical proteins and their annotated locations for XP_011248501.1

    Conserved Domains (1) summary
    cd19141
    Location:38363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  3. XM_006538586.4XP_006538649.1  voltage-gated potassium channel subunit beta-2 isoform X4

    See identical proteins and their annotated locations for XP_006538649.1

    Conserved Domains (1) summary
    cd19141
    Location:25349
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  4. XM_030253267.1XP_030109127.1  voltage-gated potassium channel subunit beta-2 isoform X5

    Conserved Domains (1) summary
    cd19141
    Location:38347
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  5. XM_006538585.4XP_006538648.1  voltage-gated potassium channel subunit beta-2 isoform X3

    See identical proteins and their annotated locations for XP_006538648.1

    Conserved Domains (1) summary
    cd19141
    Location:38363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  6. XM_006538584.5XP_006538647.1  voltage-gated potassium channel subunit beta-2 isoform X3

    See identical proteins and their annotated locations for XP_006538647.1

    Conserved Domains (1) summary
    cd19141
    Location:38363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  7. XM_006538587.5XP_006538650.1  voltage-gated potassium channel subunit beta-2 isoform X4

    See identical proteins and their annotated locations for XP_006538650.1

    Conserved Domains (1) summary
    cd19141
    Location:25349
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  8. XM_036163742.1XP_036019635.1  voltage-gated potassium channel subunit beta-2 isoform X3

    Conserved Domains (1) summary
    cd19141
    Location:38363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  9. XM_011250198.3XP_011248500.1  voltage-gated potassium channel subunit beta-2 isoform X2

    Related
    ENSMUSP00000158771.2, ENSMUST00000238252.2
    Conserved Domains (1) summary
    cd19141
    Location:69378
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
  10. XM_011250197.4XP_011248499.1  voltage-gated potassium channel subunit beta-2 isoform X1

    Conserved Domains (1) summary
    cd19141
    Location:69394
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
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