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Kcnb1 potassium voltage gated channel, Shab-related subfamily, member 1 [ Mus musculus (house mouse) ]

Gene ID: 16500, updated on 23-Jun-2021

Summary

Official Symbol
Kcnb1provided by MGI
Official Full Name
potassium voltage gated channel, Shab-related subfamily, member 1provided by MGI
Primary source
MGI:MGI:96666
See related
Ensembl:ENSMUSG00000050556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sh; Kv2.; Shab; Kcr1-; Kv2.1; Kcr1-1
Expression
Broad expression in cortex adult (RPKM 12.1), frontal lobe adult (RPKM 11.6) and 19 other tissues See more
Orthologs
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Genomic context

See Kcnb1 in Genome Data Viewer
Location:
2 H3; 2 87.22 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (166937889..167032088, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (167095969..167190072, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (166928878..167014299, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene Neighboring gene selenoprotein K pseudogene Neighboring gene predicted gene, 52568 Neighboring gene RIKEN cDNA 1110018N20 gene Neighboring gene prostaglandin I2 (prostacyclin) synthase Neighboring gene predicted gene, 52569 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables delayed rectifier potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables outward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of catecholamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of motor neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle docking involved in exocytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily B member 1
Names
voltage-gated potassium channel subunit Kv2.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008420.4NP_032446.2  potassium voltage-gated channel subfamily B member 1

    See identical proteins and their annotated locations for NP_032446.2

    Status: VALIDATED

    Source sequence(s)
    AL591711, AL591854, BC061501
    Consensus CDS
    CCDS17096.1
    UniProtKB/Swiss-Prot
    Q03717
    Related
    ENSMUSP00000147093.2, ENSMUST00000207917.2
    Conserved Domains (3) summary
    cd18412
    Location:15141
    BTB_POZ_KCNB2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2)
    pfam00520
    Location:188424
    Ion_trans; Ion transport protein
    pfam03521
    Location:467678
    Kv2channel; Kv2 voltage-gated K+ channel

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    166937889..167032088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315732.3XP_017171221.1  potassium voltage-gated channel subfamily B member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q03717
    Related
    ENSMUSP00000057981.8, ENSMUST00000059826.10
    Conserved Domains (3) summary
    cd18412
    Location:15141
    BTB_POZ_KCNB2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2)
    pfam00520
    Location:188424
    Ion_trans; Ion transport protein
    pfam03521
    Location:467678
    Kv2channel; Kv2 voltage-gated K+ channel

RNA

  1. XR_001781070.3 RNA Sequence

  2. XR_374417.4 RNA Sequence

  3. XR_374418.4 RNA Sequence

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