Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnd2provided by MGI
Official Full Name: potassium voltage-gated channel, Shal-related family, member 2provided by MGI
Primary source: MGI:MGI:102663
See related: Ensembl:ENSMUSG00000060882 AllianceGenome:MGI:102663
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kv4.2; Gm52855
Summary: Enables A-type (transient outward) potassium channel activity and voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including locomotor rhythm; neuronal action potential; and potassium ion transmembrane transport. Acts upstream of or within action potential. Located in several cellular components, including GABA-ergic synapse; dendritic spine; and postsynaptic membrane. Is integral component of postsynaptic membrane. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic specialization membrane. Is expressed in several structures, including heart; hindlimb digit; metanephros; nervous system; and sensory organ. Orthologous to human KCND2 (potassium voltage-gated channel subfamily D member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 27.7), frontal lobe adult (RPKM 12.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A2- A3.1; 6 8.49 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (21212101..21729804)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (21215346..21729805)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Voltage-dependent potassium channel Kv4.2 alleviates the ischemic stroke impairments through activating neurogenesis.
Title: Voltage-dependent potassium channel Kv4.2 alleviates the ischemic stroke impairments through activating neurogenesis.
The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice.
Title: The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice.
Study uncovers increased levels of active GSK3beta in the nucleus accumbens (NAc) of mice with a depressive-like phenotype induced by chronic stress. Increased levels of active GSK3beta within the NAc of these mice lead to altered synaptic plasticity in medium spiny neurons through phosphorylation of the Kv4.2 subunit uncovering molecular mechanism of underlying depression-like behaviors.
Title: Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4.2 channels.
activity-induced Kv4.2 phosphorylation triggers Pin1 binding to, and isomerization of, Kv4.2 at the pThr(607)-Pro motif, leading to the dissociation of the Kv4.2-DPP6 complex.
Title: Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility.
Results identify the functional interaction between GSK3beta and Kv4.2 channel as a novel mechanism for long-term depression modulation providing exciting insight into the understanding of GSK3beta role in synaptic plasticity.
Title: GSK3β Modulates Timing-Dependent Long-Term Depression Through Direct Phosphorylation of Kv4.2 Channels.
Kv4 interacting dynamically with persistent sodium currents is a key determinant of the irregular firing behaviour of Kiss1(Arc) neurons.
Title: Kv4.2 channel activity controls intrinsic firing dynamics of arcuate kisspeptin neurons.
we are investigating the effects of hyperoxia on atrial electrophysiology using whole-cell patch-clamp electrophysiology experiments along with assessment of Kv1.5, Kv4.2, and KChIP2 transcripts and protein profiles using real-time quantitative RT-PCR and Western blotting.
Title: Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes.
The results reveal an important role for miR-324-5p-mediated silencing of Kv4.2 in seizure onset.
Title: MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset.
Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
Title: Neuritin Up-regulates Kv4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.
Result suggests that the memory type supported by neurons may depend critically on the phosphorylation of specific K+ channels at single residues.
Title: Phosphorylation of K+ channels at single residues regulates memory formation.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132271 (e-PCR)
- UniSTS:215554

D6Mit306 (e-PCR), detects polymorphism
- UniSTS:130858

AW554807 (e-PCR)
- UniSTS:185654

37.MMHAP37FRE10.seq (e-PCR)
- UniSTS:124231

MDB1071 (e-PCR)
- UniSTS:125044

AI848395 (e-PCR)
- UniSTS:179340

UniSTS:498320 (e-PCR)
- UniSTS:498320

Kcnd2 (e-PCR), detects polymorphism
- UniSTS:498320

AW555701 (e-PCR)
- UniSTS:179344

AI839615 (e-PCR)
- UniSTS:179345

RH125168 (e-PCR)
- UniSTS:161990

D6Mit266 (e-PCR), detects polymorphism
- UniSTS:130815

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables A-type (transient outward) potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables A-type (transient outward) potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables A-type (transient outward) potassium channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in action potential	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart contraction	NAS Non-traceable Author Statement more info	PubMed
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of Kv4.2-KChIP2 channel complex	ISO Inferred from Sequence Orthology more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily D member 2

Names: voltage-gated potassium channel subunit Kv4.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019697.4 → NP_062671.1 potassium voltage-gated channel subfamily D member 2

See identical proteins and their annotated locations for NP_062671.1

Status: VALIDATED

Source sequence(s)

BC079667, BY279027, CB520748

Consensus CDS

CCDS19934.1

UniProtKB/Swiss-Prot

Q8BSK3, Q8CHB7, Q9JJ60, Q9Z0V2

Related

ENSMUSP00000080257.6, ENSMUST00000081542.6

Conserved Domains (6) summary

smart00225
Location:43 → 140

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:216 → 415

Ion_trans; Ion transport protein

pfam02214
Location:43 → 132

BTB_2; BTB/POZ domain

pfam07885
Location:331 → 411

Ion_trans_2; Ion channel

pfam11601
Location:3 → 28

Shal-type; Shal-type voltage-gated potassium channels

pfam11879
Location:445 → 546

DUF3399; Domain of unknown function (DUF3399)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

21212101..21729804

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165884.1 → XP_036021777.1 potassium voltage-gated channel subfamily D member 2 isoform X1

Conserved Domains (2) summary

cl38908
Location:6 → 144

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:184 → 373

Ion_trans; Ion transport protein