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Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 [ Mus musculus (house mouse) ]

Gene ID: 16534, updated on 6-Sep-2021

Summary

Official Symbol
Kcnn4provided by MGI
Official Full Name
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4provided by MGI
Primary source
MGI:MGI:1277957
See related
Ensembl:ENSMUSG00000054342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IK; SK; IK1; IKC; SK4; KCA4; mIKC; IKCA1; KCa3.; SKCas; KCa3.1; mIKCa1
Expression
Biased expression in thymus adult (RPKM 85.0), liver E14.5 (RPKM 56.8) and 11 other tissues See more
Orthologs
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Genomic context

See Kcnn4 in Genome Data Viewer
Location:
7; 7 A3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24069251..24084637)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24369826..24385212)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (25155282..25170231)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Ly6/Plaur domain containing 5 Neighboring gene predicted gene, 38964 Neighboring gene SMG9 nonsense mediated mRNA decay factor Neighboring gene immunity-related GTPase family, cinema 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
intermediate conductance calcium-activated potassium channel protein 4
Names
SKCa 4
SKCa4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163510.1NP_001156982.1  intermediate conductance calcium-activated potassium channel protein 4

    See identical proteins and their annotated locations for NP_001156982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 3' UTR, compared to variant 1.
    Source sequence(s)
    AK010943, AK155910, BX639773
    Consensus CDS
    CCDS20948.1
    UniProtKB/Swiss-Prot
    O89109
    Related
    ENSMUSP00000133065.2, ENSMUST00000171904.3
    Conserved Domains (3) summary
    smart01053
    Location:302374
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:15121
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:235288
    Ion_trans_2; Ion channel
  2. NM_008433.4NP_032459.3  intermediate conductance calcium-activated potassium channel protein 4

    See identical proteins and their annotated locations for NP_032459.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AK010943, AK085752, AK155910, BX639773
    Consensus CDS
    CCDS20948.1
    UniProtKB/Swiss-Prot
    O89109
    Related
    ENSMUSP00000146012.2, ENSMUST00000205428.2
    Conserved Domains (3) summary
    smart01053
    Location:302374
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:15121
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:235288
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24069251..24084637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539563.4XP_006539626.1  intermediate conductance calcium-activated potassium channel protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006539626.1

    UniProtKB/Swiss-Prot
    O89109
    Conserved Domains (3) summary
    smart01053
    Location:302374
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:15121
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:235288
    Ion_trans_2; Ion channel

RNA

  1. XR_003946402.1 RNA Sequence

  2. XR_391046.4 RNA Sequence

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