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Napsa napsin A aspartic peptidase [ Mus musculus (house mouse) ]

Gene ID: 16541, updated on 23-Jun-2021

Summary

Official Symbol
Napsaprovided by MGI
Official Full Name
napsin A aspartic peptidaseprovided by MGI
Primary source
MGI:MGI:109365
See related
Ensembl:ENSMUSG00000002204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N; Kd; KAP; Kdap; NAP1; SNAPA; pronapsin
Expression
Biased expression in kidney adult (RPKM 2223.2) and lung adult (RPKM 258.7) See more
Orthologs
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Genomic context

See Napsa in Genome Data Viewer
Location:
7; 7 B3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44221869..44236270)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44572445..44586846)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (51827815..51842216)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053 Neighboring gene nuclear receptor subfamily 1, group H, member 2 Neighboring gene predicted gene 15396 Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 3 Neighboring gene myosin, heavy polypeptide 14 Neighboring gene E1A binding protein p300 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in membrane protein proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane protein proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in alveolar lamellar body IDA
Inferred from Direct Assay
more info
PubMed 
located_in alveolar lamellar body ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
napsin-A
Names
KDAP-1
kidney-derived aspartic protease-like protein
NP_032463.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008437.1NP_032463.1  napsin-A precursor

    See identical proteins and their annotated locations for NP_032463.1

    Status: VALIDATED

    Source sequence(s)
    D88899
    Consensus CDS
    CCDS21212.1
    UniProtKB/Swiss-Prot
    O09043
    UniProtKB/TrEMBL
    Q3U7H1
    Related
    ENSMUSP00000002274.9, ENSMUST00000002274.10
    Conserved Domains (2) summary
    pfam00026
    Location:72396
    Asp; Eukaryotic aspartyl protease
    cl11403
    Location:68394
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44221869..44236270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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