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Khk ketohexokinase [ Mus musculus (house mouse) ]

Gene ID: 16548, updated on 23-Jun-2021

Summary

Official Symbol
Khkprovided by MGI
Official Full Name
ketohexokinaseprovided by MGI
Primary source
MGI:MGI:1096353
See related
Ensembl:ENSMUSG00000029162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in kidney adult (RPKM 274.9), liver adult (RPKM 172.1) and 4 other tissues See more
Orthologs
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Genomic context

See Khk in Genome Data Viewer
Location:
5 B1; 5 16.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31078780..31088592)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30921436..30931248)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (31224268..31233619)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 5 Neighboring gene oligosaccharyltransferase complex subunit 4 (non-catalytic) Neighboring gene elastin microfibril interfacer 1 Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene abhydrolase domain containing 1 Neighboring gene prolactin regulatory element binding

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ketohexokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ketohexokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ketohexokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate IC
Inferred by Curator
more info
PubMed 
involved_in fructose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within fructose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fructose metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glycolytic process through fructose-1-phosphate IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glycogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to fructose IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to glucose IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to sucrose IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to sucrose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ketohexokinase
Names
hepatic fructokinase
NP_001297453.1
NP_001297454.1
NP_001335995.1
NP_032465.2
XP_006503811.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310524.1NP_001297453.1  ketohexokinase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC109606
    Consensus CDS
    CCDS80243.1
    UniProtKB/TrEMBL
    E9Q1Q9
    Related
    ENSMUSP00000031053.10, ENSMUST00000031053.15
    Conserved Domains (1) summary
    cd01939
    Location:5340
    Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
  2. NM_001310525.1NP_001297454.1  ketohexokinase isoform 3

    See identical proteins and their annotated locations for NP_001297454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC109606
    UniProtKB/TrEMBL
    A0A0J9YUK6
    Related
    ENSMUSP00000144226.2, ENSMUST00000201571.4
    Conserved Domains (1) summary
    cd01939
    Location:5250
    Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
  3. NM_001349066.1NP_001335995.1  ketohexokinase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC109606
    Related
    ENSMUSP00000143850.2, ENSMUST00000202752.2
    Conserved Domains (1) summary
    cd01939
    Location:5295
    Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
  4. NM_008439.4NP_032465.2  ketohexokinase isoform 2

    See identical proteins and their annotated locations for NP_032465.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC109606
    Consensus CDS
    CCDS39050.1
    UniProtKB/Swiss-Prot
    P97328
    UniProtKB/TrEMBL
    A0A0J9YU79
    Related
    ENSMUSP00000144050.2, ENSMUST00000201621.4
    Conserved Domains (1) summary
    cd01939
    Location:5295
    Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31078780..31088592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503748.2XP_006503811.1  ketohexokinase isoform X1

    Conserved Domains (1) summary
    cd01939
    Location:5302
    Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
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