Kifap3 kinesin-associated protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kifap3provided by MGI
Official Full Name: kinesin-associated protein 3provided by MGI
Primary source: MGI:MGI:107566
See related: Ensembl:ENSMUSG00000026585 AllianceGenome:MGI:107566
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KAP3; SMAP; KAP-3
Summary: The protein encoded by this gene is the non-motor subunit of kinesin-2 complex, and forms a heterotrimer with two members of the kinesin superfamily of proteins that together form a microtubule plus-end directed translocator that plays an important role in intracellular transport, mitosis, and cell-cell adhesion. This protein contains multiple armadillo repeats involved in protein binding, and may serve as an adaptor to regulate binding of cargo with the motor proteins. Conditional disruption of this gene in mouse neural precursor cells caused a tumor-like phenotype and defective organization of the neuroepithelium thought to be the result of altered N-cadherin subcellular localization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Expression: Broad expression in CNS E18 (RPKM 36.2), cortex adult (RPKM 29.0) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.1; 1 71.08 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (163589711..163744676)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (163762138..163917107)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling.
Title: The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling.
SOD1 associates specifically KAP3 in the ventral white matter of SOD1 transgenic mouse.
Title: Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3.
Interaction of KIF3A/3B with KAP3 may be important for the proper progression of mitosis.
Title: Role of the kinesin-2 family protein, KIF3, during mitosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables intraciliary transport particle B binding	IDA Inferred from Direct Assay more info	PubMed
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of thymocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of calcium-dependent cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of thymocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary transition zone	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of kinesin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin II complex	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin II complex	IPI Inferred from Physical Interaction more info	PubMed
part_of kinesin II complex	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in periciliary membrane compartment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor connecting cilium	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305643.1 → NP_001292572.1 kinesin-associated protein 3 isoform KAP3A

See identical proteins and their annotated locations for NP_001292572.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (KAP3A, PMID:8710890).

Source sequence(s)

AK013954, AK133957, BC040362, BU701040

Consensus CDS

CCDS78729.1

UniProtKB/Swiss-Prot

P70188, P70189, Q6GTS3

UniProtKB/TrEMBL

Q3UZA5

Related

ENSMUSP00000027877.6, ENSMUST00000027877.7

Conserved Domains (2) summary

cd00020
Location:578 → 662

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05804
Location:13 → 720

KAP; Kinesin-associated protein (KAP)
NM_010629.3 → NP_034759.1 kinesin-associated protein 3 isoform KAP3B

See identical proteins and their annotated locations for NP_034759.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region and differs in its 3' UTR, compared to variant 1. The encoded isoform (KAP3B, PMID:8710890) is shorter and has a distinct C-terminus, compared to KAP3A.

Source sequence(s)

AK013954, BC040362, BU701040

Consensus CDS

CCDS35751.1

UniProtKB/TrEMBL

Q3UZA5

Related

ENSMUSP00000076830.6, ENSMUST00000077642.12

Conserved Domains (2) summary

cd00020
Location:578 → 662

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05804
Location:13 → 720

KAP; Kinesin-associated protein (KAP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

163589711..163744676

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496681.4 → XP_006496744.1 kinesin-associated protein 3 isoform X2

UniProtKB/TrEMBL

Q3UZA5

Conserved Domains (1) summary

pfam05804
Location:29 → 736

KAP; Kinesin-associated protein (KAP)
XM_006496679.4 → XP_006496742.1 kinesin-associated protein 3 isoform X1

UniProtKB/TrEMBL

Q3UZA5

Conserved Domains (1) summary

pfam05804
Location:29 → 736

KAP; Kinesin-associated protein (KAP)