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Klk1b24 kallikrein 1-related peptidase b24 [ Mus musculus (house mouse) ]

Gene ID: 16617, updated on 8-Feb-2024

Summary

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Official Symbol
Klk1b24provided by MGI
Official Full Name
kallikrein 1-related peptidase b24provided by MGI
Primary source
MGI:MGI:892021
See related
Ensembl:ENSMUSG00000063713 AllianceGenome:MGI:892021
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Klk24; mGk-24
Summary
This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]
Expression
Biased expression in colon adult (RPKM 79.3), kidney adult (RPKM 55.5) and 5 other tissues See more
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Genomic context

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See Klk1b24 in Genome Data Viewer
Location:
7 B3; 7 28.7 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43837658..43841879)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44188234..44192455)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein 1-related peptidase b22 Neighboring gene kallikrein 1-related peptidase b16 Neighboring gene kallikrein 1-related peptidase b23, pseudogene Neighboring gene STARR-seq mESC enhancer starr_18787 Neighboring gene kallikrein 1-related peptidase b3 Neighboring gene kallikrein 1-related pepidase b4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Single-chain tissue-type plasminogen activator is a substrate of mouse glandular kallikrein 24. Matsui H, et al. Zoolog Sci, 2005 Oct. PMID 16286722
  2. Characterization of mouse glandular kallikrein 24 expressed in testicular Leydig cells. Matsui H, et al. Int J Biochem Cell Biol, 2005 Nov. PMID 15985384
  3. Cloning and characterization of mouse klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity. Matsui H, et al. Eur J Biochem, 2000 Dec. PMID 11082197
  4. Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome. Isbel L, et al. PLoS Genet, 2015 Dec. PMID 26624618, Free PMC Article
  5. Mouse glandular kallikrein genes. Identification, structure, and expression of the renal kallikrein gene. van Leeuwen BH, et al. J Biol Chem, 1986 Apr 25. PMID 3007510

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteolysis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kallikrein 1-related peptidase b24
Names
glandular kallikrein K24
tissue kallikrein 24
NP_034773.1
XP_006540737.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010643.2 → NP_034773.1  kallikrein 1-related peptidase b24 preproprotein

    See identical proteins and their annotated locations for NP_034773.1

    Status: REVIEWED

    Source sequence(s)
    AB039277, BC146019
    Consensus CDS
    CCDS21198.1
    UniProtKB/Swiss-Prot
    A6H6V7, Q61754, Q61755, Q9JM69
    Related
    ENSMUSP00000073392.7, ENSMUST00000073713.8
    Conserved Domains (2) summary
    smart00020
    Location:24 → 255
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:25 → 258
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43837658..43841879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540674.3 → XP_006540737.1  kallikrein 1-related peptidase b24 isoform X1

    UniProtKB/TrEMBL
    A0A1R3UCH3
    Conserved Domains (1) summary
    smart00020
    Location:24 → 252
    Tryp_SPc; Trypsin-like serine protease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61754.3 GenPept UniProtKB/Swiss-Prot:Q61754

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