Klrd1 killer cell lectin-like receptor, subfamily D, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klrd1provided by MGI
Official Full Name: killer cell lectin-like receptor, subfamily D, member 1provided by MGI
Primary source: MGI:MGI:1196275
See related: Ensembl:ENSMUSG00000030165 AllianceGenome:MGI:1196275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD94
Summary: Predicted to enable HLA-E specific inhibitory MHC class Ib receptor activity; MHC protein complex binding activity; and protein antigen binding activity. Predicted to be involved in natural killer cell mediated immunity; regulation of leukocyte mediated cytotoxicity; and stimulatory C-type lectin receptor signaling pathway. Predicted to act upstream of or within adaptive immune response and innate immune response. Located in external side of plasma membrane. Orthologous to human KLRD1 (killer cell lectin like receptor D1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.42 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129565055..129575738)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129588092..129598775)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that the Cd94(LocA)/NKG2A receptor (NKG2A) heterodimeric receptor is widely expressed among M. musculus subspecies musculus.
Title: Evidence of functional Cd94 polymorphism in a free-living house mouse population.
Segregation of a spontaneous Klrd1 mutation in DBA/2 mouse substrains
Title: Segregation of a spontaneous Klrd1 (CD94) mutation in DBA/2 mouse substrains.
The transmembrane region sequences of CD94 and NKG2 in mouse and rat differ markedly from other mammalian orthologs by the presence of a lysine residue in the transmembrane region.
Title: Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
The complex interplay between various stimuli may account for the variable expression of CD94/NKG2A during responses to different pathogens in vivo.
Title: Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells.
expression of CD94 and its associated NKG2A, NKG2C, and NKG2E subunits is dispensable for NK cell development, education, and many NK cell functions
Title: Development and function of CD94-deficient natural killer cells.
show that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus
Title: CD94 is essential for NK cell-mediated resistance to a lethal viral disease.
CD94 is an Ag that can be used to identify functionally distinct NK cell subsets in mice and could also be relevant to late-stage mouse NK cell development.
Title: CD94 defines phenotypically and functionally distinct mouse NK cell subsets.
CD94 and NKG2 were both expressed early in NK cell development, sometimes in the absence of NK1.1, with CD94 invariably being expressed at two different levels. IL-4 differentially inhibited the expression of CD94 and Ly49 receptors.
Title: NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2.
There is no evidence that CD94 inhibits either the lytic function of lymphocytic choriomeningitis virus-specific T cells or their capacity to produce effector cytokines upon peptide stimulation.
Title: CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
results indicate that LTbetaR-mediated signals are not required for Ly49 and CD94/NKG2 receptor acquisition on NK cells
Title: Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Klrd1 (e-PCR), detects polymorphism
- UniSTS:143719

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables HLA-E specific inhibitory MHC class Ib receptor activity	ISO Inferred from Sequence Orthology more info
enables MHC class I protein complex binding	ISO Inferred from Sequence Orthology more info
enables MHC class Ib protein binding, via antigen binding groove	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein antigen binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in regulation of natural killer cell activation	NAS Non-traceable Author Statement more info	PubMed
involved_in stimulatory C-type lectin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in stimulatory C-type lectin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: natural killer cells antigen CD94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010654.4 → NP_034784.1 natural killer cells antigen CD94

See identical proteins and their annotated locations for NP_034784.1

Status: VALIDATED

Source sequence(s)

AK136548, AK162976

Consensus CDS

CCDS57456.1

UniProtKB/Swiss-Prot

O54707, O54708

UniProtKB/TrEMBL

A0A346A5N7

Related

ENSMUSP00000107694.3, ENSMUST00000112063.9

Conserved Domains (1) summary

cd03593
Location:61 → 176

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

129565055..129575738

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505655.3 → XP_006505718.1 natural killer cells antigen CD94 isoform X1

See identical proteins and their annotated locations for XP_006505718.1

UniProtKB/Swiss-Prot

O54707, O54708

UniProtKB/TrEMBL

A0A346A5N7

Conserved Domains (1) summary

cd03593
Location:61 → 176

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
XM_006505656.1 → XP_006505719.1 natural killer cells antigen CD94 isoform X2

UniProtKB/TrEMBL

A0A346A5N7

Conserved Domains (2) summary

cd03593
Location:52 → 153

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:9 → 41

Ly49; Ly49-like protein, N-terminal region