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TRIM60 tripartite motif containing 60 [ Homo sapiens (human) ]

Gene ID: 166655, updated on 5-Mar-2024

Summary

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Official Symbol
TRIM60provided by HGNC
Official Full Name
tripartite motif containing 60provided by HGNC
Primary source
HGNC:HGNC:21162
See related
Ensembl:ENSG00000176979 MIM:619416; AllianceGenome:HGNC:21162
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF33; RNF129
Summary
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
4q32.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (165031999..165041749)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (168379481..168389231)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (165953151..165962901)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 75 pseudogene Neighboring gene tripartite motif-containing 75 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:165952653-165953309 Neighboring gene tripartite motif containing 75 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:165990521-165991020 Neighboring gene transmembrane protein 192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22115 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15782 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:166033986-166034184

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response. Gu Z, et al. Cell Mol Immunol, 2021 Aug. PMID 33184450, Free PMC Article
  2. Does this have a familiar RING? Saurin AJ, et al. Trends Biochem Sci, 1996 Jun. PMID 8744354
  3. Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. Silva LE, et al. J Proteome Res, 2019 Oct 4. PMID 31478661
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061
  5. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. Wang B, et al. EBioMedicine, 2019 Mar. PMID 30745168, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35882, MGC119325

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SUMO-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 60
Names
ring finger protein 129
ring finger protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258025.2 → NP_001244954.1  tripartite motif-containing protein 60

    See identical proteins and their annotated locations for NP_001244954.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC106872, BC100986
    Consensus CDS
    CCDS3808.1
    UniProtKB/Swiss-Prot
    Q495X7, Q8NA35
    Related
    ENSP00000426496.1, ENST00000508504.1
    Conserved Domains (5) summary
    cd15828
    Location:286 → 465
    SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
    pfam00643
    Location:92 → 133
    zf-B_box; B-box zinc finger
    pfam15905
    Location:139 → 260
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
    cd16607
    Location:13 → 59
    RING-HC_TRIM60_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61 and similar proteins
    cl26688
    Location:16 → 105
    DWNN; DWNN domain

  2. NM_152620.3 → NP_689833.1  tripartite motif-containing protein 60

    See identical proteins and their annotated locations for NP_689833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC106872, AK093201
    Consensus CDS
    CCDS3808.1
    UniProtKB/Swiss-Prot
    Q495X7, Q8NA35
    Related
    ENSP00000421142.1, ENST00000512596.6
    Conserved Domains (5) summary
    cd15828
    Location:286 → 465
    SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
    pfam00643
    Location:92 → 133
    zf-B_box; B-box zinc finger
    pfam15905
    Location:139 → 260
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
    cd16607
    Location:13 → 59
    RING-HC_TRIM60_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61 and similar proteins
    cl26688
    Location:16 → 105
    DWNN; DWNN domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    165031999..165041749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531683.3 → XP_011529985.1  tripartite motif-containing protein 60 isoform X1

    See identical proteins and their annotated locations for XP_011529985.1

    UniProtKB/Swiss-Prot
    Q495X7, Q8NA35
    Conserved Domains (5) summary
    cd15828
    Location:286 → 465
    SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
    pfam00643
    Location:92 → 133
    zf-B_box; B-box zinc finger
    pfam15905
    Location:139 → 260
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
    cd16607
    Location:13 → 59
    RING-HC_TRIM60_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61 and similar proteins
    cl26688
    Location:16 → 105
    DWNN; DWNN domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    168379481..168389231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349100.1 → XP_054205075.1  tripartite motif-containing protein 60 isoform X1

    UniProtKB/Swiss-Prot
    Q495X7, Q8NA35
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q495X7.2 GenPept UniProtKB/Swiss-Prot:Q495X7

Gene LinkOut

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