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Krt86 keratin 86 [ Mus musculus (house mouse) ]

Gene ID: 16679, updated on 8-Feb-2024

Summary

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Official Symbol
Krt86provided by MGI
Official Full Name
keratin 86provided by MGI
Primary source
MGI:MGI:109362
See related
Ensembl:ENSMUSG00000067614 AllianceGenome:MGI:109362
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Khb4; MHb4; Krt2-10; Krt2-11; 5430421N21Rik
Summary
Predicted to be located in keratin filament. Is expressed in digit epidermis and hair shaft. Human ortholog(s) of this gene implicated in hair disease and monilethrix. Orthologous to human KRT86 (keratin 86). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
15 F2; 15 56.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101371359..101377864)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101473478..101479983)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 88 Neighboring gene keratin 81 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:101316581-101316768 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:101316810-101316963 Neighboring gene keratin 83 Neighboring gene STARR-seq mESC enhancer starr_39797 Neighboring gene type II keratin Kb32P

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alternative splicing of amelogenins. Simmer JP. Connect Tissue Res, 1995. PMID 7554909
  2. Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins. Yu DW, et al. J Invest Dermatol, 1991 Aug. PMID 1712823
  3. Structure and site of expression of a murine type II hair keratin. Tobiasch E, et al. Mol Biol Rep, 1992 Feb. PMID 1372089
  4. Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs. Knapp B, et al. Nucleic Acids Res, 1986 Jan 24. PMID 2418416, Free PMC Article
  5. Sequences and differential expression of three novel human type-II hair keratins. Rogers MA, et al. Differentiation, 1997 Feb. PMID 9084137

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
keratin, type II cuticular Hb6
Names
K86
keratin complex 2, basic, gene 10
type II hair keratin Hb6
type-II keratin Kb26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010667.2 → NP_034797.1  keratin, type II cuticular Hb6

    See identical proteins and their annotated locations for NP_034797.1

    Status: PROVISIONAL

    Source sequence(s)
    AK161149
    Consensus CDS
    CCDS37218.1
    UniProtKB/Swiss-Prot
    P97861, Q3TTV9
    UniProtKB/TrEMBL
    B2RTB6, Q61726
    Related
    ENSMUSP00000085365.4, ENSMUST00000088049.5
    Conserved Domains (3) summary
    pfam00038
    Location:105 → 416
    Filament; Intermediate filament protein
    pfam16208
    Location:4 → 102
    Keratin_2_head; Keratin type II head
    cl23720
    Location:315 → 383
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101371359..101377864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97861.2 GenPept UniProtKB/Swiss-Prot:P97861

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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