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Krt4 keratin 4 [ Mus musculus (house mouse) ]

Gene ID: 16682, updated on 24-Apr-2022

Summary

Official Symbol
Krt4provided by MGI
Official Full Name
keratin 4provided by MGI
Primary source
MGI:MGI:96701
See related
Ensembl:ENSMUSG00000059668 AllianceGenome:MGI:96701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K4; Krt2-4; Krt-2.4; AW108092
Summary
Involved in epithelial cell differentiation and negative regulation of epithelial cell proliferation. Predicted to be located in cell surface and keratin filament. Is expressed in several structures, including alimentary system; lower urinary tract; sensory organ; skin; and trachea. Used to study hereditary mucosal leukokeratosis. Human ortholog(s) of this gene implicated in hereditary mucosal leukokeratosis. Orthologous to human KRT4 (keratin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 371.2), stomach adult (RPKM 351.0) and 1 other tissue See more
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Genomic context

See Krt4 in Genome Data Viewer
Location:
15 F2; 15 57.13 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101826970..101833170, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101918535..101924735, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (101748966..101755166, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 77 Neighboring gene keratin 76 Neighboring gene keratin 79 Neighboring gene keratin 78

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
 
located_in keratin filament TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
keratin, type II cytoskeletal 4
Names
57kDa keratin
57kd keratin
CK-4
cytokeratin-4
cytoskeletal 57 kDa keratin
keratin complex 2, basic, gene 4
type-II keratin Kb4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008475.2NP_032501.2  keratin, type II cytoskeletal 4

    See identical proteins and their annotated locations for NP_032501.2

    Status: VALIDATED

    Source sequence(s)
    BC064008, BY139439
    Consensus CDS
    CCDS37222.1
    UniProtKB/Swiss-Prot
    P07744
    Related
    ENSMUSP00000023797.7, ENSMUST00000023797.8
    Conserved Domains (3) summary
    pfam00038
    Location:146458
    Filament; Intermediate filament protein
    pfam16208
    Location:14142
    Keratin_2_head; Keratin type II head
    cl23720
    Location:366433
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101826970..101833170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)