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Lama2 laminin, alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 16773, updated on 12-Aug-2019

Summary

Official Symbol
Lama2provided by MGI
Official Full Name
laminin, alpha 2provided by MGI
Primary source
MGI:MGI:99912
See related
Ensembl:ENSMUSG00000019899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dy; mer; merosin; mKIAA4087; 5830440B04
Expression
Broad expression in bladder adult (RPKM 7.3), heart adult (RPKM 7.3) and 22 other tissues See more
Orthologs

Genomic context

See Lama2 in Genome Data Viewer
Location:
10 A4; 10 14.23 cM
Exon count:
66
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (26981285..27617191, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (26701091..27336748, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 18 Neighboring gene predicted gene, 30534 Neighboring gene predicted gene, 40618 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene RIKEN cDNA 4930579H20 gene Neighboring gene predicted gene, 30165 Neighboring gene predicted gene, 30228 Neighboring gene predicted gene, 18041

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...
  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • ECM-receptor interaction, organism-specific biosystem (from KEGG)
    ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • ECM-receptor interaction, conserved biosystem (from KEGG)
    ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
    Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Laminin interactions, organism-specific biosystem (from REACTOME)
    Laminin interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • MET activates PTK2 signaling, organism-specific biosystem (from REACTOME)
    MET activates PTK2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • MET promotes cell motility, organism-specific biosystem (from REACTOME)
    MET promotes cell motility, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Non-integrin membrane-ECM interactions, organism-specific biosystem (from REACTOME)
    Non-integrin membrane-ECM interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by MET, organism-specific biosystem (from REACTOME)
    Signaling by MET, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Small cell lung cancer, organism-specific biosystem (from KEGG)
    Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Small cell lung cancer, conserved biosystem (from KEGG)
    Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Viral myocarditis, organism-specific biosystem (from KEGG)
    Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4087

Gene Ontology Provided by MGI

Function Evidence Code Pubs
extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
basement membrane ISO
Inferred from Sequence Orthology
more info
 
collagen-containing extracellular matrix HDA PubMed 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
laminin subunit alpha-2
Names
dystrophia muscularis
laminin M chain
laminin-12 subunit alpha
laminin-2 subunit alpha
laminin-4 subunit alpha
merosin heavy chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008481.2NP_032507.2  laminin subunit alpha-2 precursor

    See identical proteins and their annotated locations for NP_032507.2

    Status: VALIDATED

    Source sequence(s)
    AC153800, AK030879, AK076479, AK220480, BB637328, BC039991, CD350015
    Consensus CDS
    CCDS48526.1
    UniProtKB/Swiss-Prot
    Q60675
    UniProtKB/TrEMBL
    Q5DTP0
    Related
    ENSMUSP00000090304.5, ENSMUST00000092639.11
    Conserved Domains (12) summary
    smart00180
    Location:9631007
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:12251360
    LamB; Laminin B domain
    cd00055
    Location:913960
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:29373089
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00052
    Location:579707
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:10561104
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:27892917
    Laminin_G_1; Laminin G domain
    pfam00055
    Location:45281
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam01442
    Location:18452059
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam06008
    Location:15841848
    Laminin_I; Laminin Domain I
    pfam06009
    Location:20332168
    Laminin_II; Laminin Domain II
    cl02488
    Location:16821881
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

    Range
    26981285..27617191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313815.1XP_017169304.1  laminin subunit alpha-2 isoform X3

  2. XM_011243134.1XP_011241436.1  laminin subunit alpha-2 isoform X1

    Conserved Domains (12) summary
    smart00180
    Location:9631007
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:12251360
    LamB; Laminin B domain
    COG0840
    Location:17252142
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd00055
    Location:913960
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:29353087
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00052
    Location:579707
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:10561104
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:27872915
    Laminin_G_1; Laminin G domain
    pfam00055
    Location:45281
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam06008
    Location:15841848
    Laminin_I; Laminin Domain I
    pfam06009
    Location:20332166
    Laminin_II; Laminin Domain II
    cl02488
    Location:16821881
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  3. XM_011243135.1XP_011241437.1  laminin subunit alpha-2 isoform X2

    Conserved Domains (12) summary
    smart00180
    Location:9631007
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:12251360
    LamB; Laminin B domain
    cd00055
    Location:913960
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:29333085
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00052
    Location:579707
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:10561104
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:27852913
    Laminin_G_1; Laminin G domain
    pfam00055
    Location:45281
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam01442
    Location:18452059
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam06008
    Location:15841848
    Laminin_I; Laminin Domain I
    pfam06009
    Location:20332168
    Laminin_II; Laminin Domain II
    cl02488
    Location:16821881
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  4. XM_006512566.4XP_006512629.1  laminin subunit alpha-2 isoform X4

    Conserved Domains (8) summary
    smart00180
    Location:9631007
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:12251360
    LamB; Laminin B domain
    cd00055
    Location:913960
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00052
    Location:579707
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:10561104
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:45281
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam06008
    Location:15841848
    Laminin_I; Laminin Domain I
    cl02488
    Location:16821881
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
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