Format

Send to:

Choose Destination

Lama2 laminin, alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 16773, updated on 8-Jul-2021

Summary

Official Symbol
Lama2provided by MGI
Official Full Name
laminin, alpha 2provided by MGI
Primary source
MGI:MGI:99912
See related
Ensembl:ENSMUSG00000019899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dy; me; mer; merosin; mKIAA4087; 5830440B04
Expression
Broad expression in bladder adult (RPKM 7.3), heart adult (RPKM 7.3) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Lama2 in Genome Data Viewer
Location:
10 A4; 10 14.23 cM
Exon count:
66
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (26857281..27493021, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (26981285..27617191, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (26701091..27336748, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 18 Neighboring gene predicted gene, 30534 Neighboring gene predicted gene, 40618 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene RIKEN cDNA 4930579H20 gene Neighboring gene predicted gene, 30165 Neighboring gene predicted gene, 30228 Neighboring gene predicted gene, 18041

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4087

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
laminin subunit alpha-2
Names
dystrophia muscularis
laminin M chain
laminin-12 subunit alpha
laminin-2 subunit alpha
laminin-4 subunit alpha
merosin heavy chain

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008481.2NP_032507.2  laminin subunit alpha-2 precursor

    See identical proteins and their annotated locations for NP_032507.2

    Status: VALIDATED

    Source sequence(s)
    AC153800, AK030879, AK076479, AK220480, BB637328, BC039991, CD350015
    Consensus CDS
    CCDS48526.1
    UniProtKB/Swiss-Prot
    Q60675
    UniProtKB/TrEMBL
    Q5DTP0
    Related
    ENSMUSP00000090304.6, ENSMUST00000092639.12
    Conserved Domains (12) summary
    smart00180
    Location:9631007
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:12251360
    LamB; Laminin B domain
    cd00055
    Location:913960
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:29373089
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00052
    Location:579707
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:10561104
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:27892917
    Laminin_G_1; Laminin G domain
    pfam00055
    Location:45281
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam01442
    Location:18452059
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam06008
    Location:15841848
    Laminin_I; Laminin Domain I
    pfam06009
    Location:20332168
    Laminin_II; Laminin Domain II
    cl02488
    Location:16821881
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    26857281..27493021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313815.1XP_017169304.1  laminin subunit alpha-2 isoform X3

    Conserved Domains (11) summary
    smart00180
    Location:9631007
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:12251360
    LamB; Laminin B domain
    COG1196
    Location:16972010
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00055
    Location:913960
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:29313083
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam06008
    Location:15891848
    Laminin_I; Laminin Domain I
    pfam00054
    Location:27832911
    Laminin_G_1; Laminin G domain
    pfam00052
    Location:579718
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:10561104
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:45281
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam06009
    Location:20332166
    Laminin_II; Laminin Domain II
  2. XM_011243134.1XP_011241436.1  laminin subunit alpha-2 isoform X1

    Conserved Domains (11) summary
    smart00180
    Location:9631007
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:12251360
    LamB; Laminin B domain
    COG1196
    Location:16972010
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00055
    Location:913960
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:29353087
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam06008
    Location:15891848
    Laminin_I; Laminin Domain I
    pfam00054
    Location:27872915
    Laminin_G_1; Laminin G domain
    pfam00052
    Location:579718
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:10561104
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:45281
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam06009
    Location:20332166
    Laminin_II; Laminin Domain II
  3. XM_011243135.1XP_011241437.1  laminin subunit alpha-2 isoform X2

    Conserved Domains (11) summary
    smart00180
    Location:9631007
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:12251360
    LamB; Laminin B domain
    COG1196
    Location:16972010
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00055
    Location:913960
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:29333085
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam06008
    Location:15891848
    Laminin_I; Laminin Domain I
    pfam00054
    Location:27852913
    Laminin_G_1; Laminin G domain
    pfam00052
    Location:579718
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:10561104
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:45281
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam06009
    Location:20332168
    Laminin_II; Laminin Domain II
  4. XM_006512566.5XP_006512629.1  laminin subunit alpha-2 isoform X4

    Conserved Domains (8) summary
    smart00180
    Location:9631007
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:12251360
    LamB; Laminin B domain
    cd00055
    Location:913960
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    TIGR02169
    Location:17581951
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam06008
    Location:15891848
    Laminin_I; Laminin Domain I
    pfam00052
    Location:579718
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:10561104
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:45281
    Laminin_N; Laminin N-terminal (Domain VI)
Support Center