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Lasp1 LIM and SH3 protein 1 [ Mus musculus (house mouse) ]

Gene ID: 16796, updated on 19-Jul-2021

Summary

Official Symbol
Lasp1provided by MGI
Official Full Name
LIM and SH3 protein 1provided by MGI
Primary source
MGI:MGI:109656
See related
Ensembl:ENSMUSG00000038366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SH3; Def-4; SH3P6; LASP-1; MLN 50; AA408629; Tg(Col1a1-lacZ)1Ngma
Expression
Ubiquitous expression in large intestine adult (RPKM 112.9), duodenum adult (RPKM 108.0) and 28 other tissues See more
Orthologs
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Genomic context

See Lasp1 in Genome Data Viewer
Location:
11 D; 11 61.1 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97689748..97729591)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97799005..97838765)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (97660986..97700078)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23 Neighboring gene small nucleolar RNA, H/ACA box 21 Neighboring gene nuclear encoded tRNA cysteine 56 (anticodon GCA) Neighboring gene nuclear encoded tRNA cysteine 51 (anticodon GCA) Neighboring gene RIKEN cDNA B230217C12 gene Neighboring gene F-box protein 47

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ion transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
LIM and SH3 domain protein 1
Names
Tg(11Col1a1)NG
metastatic lymph node gene 50 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010688.5NP_034818.1  LIM and SH3 domain protein 1

    See identical proteins and their annotated locations for NP_034818.1

    Status: VALIDATED

    Source sequence(s)
    AL596446, BE955478
    Consensus CDS
    CCDS25332.1
    UniProtKB/Swiss-Prot
    Q61792
    UniProtKB/TrEMBL
    Q543N3
    Related
    ENSMUSP00000042123.6, ENSMUST00000043843.12
    Conserved Domains (3) summary
    smart00227
    Location:98128
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:557
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11934
    Location:205263
    SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97689748..97729591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532341.2XP_006532404.1  LIM and SH3 domain protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006532404.1

    UniProtKB/Swiss-Prot
    Q61792
    UniProtKB/TrEMBL
    Q543N3
    Conserved Domains (3) summary
    smart00227
    Location:98128
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:557
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11934
    Location:205263
    SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
  2. XM_006532342.1XP_006532405.1  LIM and SH3 domain protein 1 isoform X2

    Related
    ENSMUSP00000123050.2, ENSMUST00000148280.3
    Conserved Domains (3) summary
    smart00227
    Location:6292
    NEBU; The Nebulin repeat is present also in Las1
    cd11934
    Location:169227
    SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
    cl02475
    Location:121
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
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