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Lcn2 lipocalin 2 [ Mus musculus (house mouse) ]

Gene ID: 16819, updated on 31-May-2021

Summary

Official Symbol
Lcn2provided by MGI
Official Full Name
lipocalin 2provided by MGI
Primary source
MGI:MGI:96757
See related
Ensembl:ENSMUSG00000026822
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N; 24p; NRL; 24p3; Sip24; AW212229
Expression
Biased expression in genital fat pad adult (RPKM 1633.0), liver E18 (RPKM 272.6) and 3 other tissues See more
Orthologs
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Genomic context

See Lcn2 in Genome Data Viewer
Location:
2 B; 2 22.09 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32274649..32277751, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32384637..32387739, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32240157..32243259, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene bublin coiled coil protein Neighboring gene prostaglandin E synthase 2 Neighboring gene predicted gene 13413

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enterobactin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cell projection organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to drug ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to herbicide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sequestering of iron ion ISO
Inferred from Sequence Orthology
more info
 
involved_in siderophore transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in siderophore transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neutrophil gelatinase-associated lipocalin
Names
SV-40-induced 24P3 protein
neu-related lipocalin
oncogene 24p3
p25
secreted inducible protein 24
siderocalin LCN2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008491.1NP_032517.1  neutrophil gelatinase-associated lipocalin precursor

    See identical proteins and their annotated locations for NP_032517.1

    Status: PROVISIONAL

    Source sequence(s)
    X14607
    Consensus CDS
    CCDS15913.1
    UniProtKB/Swiss-Prot
    P11672
    Related
    ENSMUSP00000053962.9, ENSMUST00000050785.14
    Conserved Domains (1) summary
    pfam00061
    Location:49195
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32274649..32277751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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