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Ldhb lactate dehydrogenase B [ Mus musculus (house mouse) ]

Gene ID: 16832, updated on 31-Aug-2021

Summary

Official Symbol
Ldhbprovided by MGI
Official Full Name
lactate dehydrogenase Bprovided by MGI
Primary source
MGI:MGI:96763
See related
Ensembl:ENSMUSG00000030246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-Ld; Ldh-; Ldh2; H-Ldh; LDH-B; LDH-H; Ldh-2; AI790582
Summary
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes 1 and 19. [provided by RefSeq, Feb 2016]
Expression
Broad expression in kidney adult (RPKM 644.8), heart adult (RPKM 618.4) and 18 other tissues See more
Orthologs
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Genomic context

See Ldhb in Genome Data Viewer
Location:
6 G2; 6 74.17 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142435975..142453683, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142490249..142507957, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (142438769..142456463, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene spexin hormone Neighboring gene glycogen synthase 2 Neighboring gene predicted gene, 38919 Neighboring gene predicted gene, 46979

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-lactate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-lactate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables lactate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in NAD metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lactate biosynthetic process from pyruvate IC
Inferred by Curator
more info
 
involved_in lactate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
L-lactate dehydrogenase B chain
Names
LDH heart subunit
lactate dehydrogenase 2, B chain
NP_001289694.1
NP_001303251.1
NP_032518.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302765.1NP_001289694.1  L-lactate dehydrogenase B chain isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and a different 3' UTR compared to variant 1. The encoded isoform (2) is shorter with a distinct C-terminus compared to isoform Ldhb.
    Source sequence(s)
    AK019391, BC046755, CX208147
    UniProtKB/Swiss-Prot
    P16125
    Conserved Domains (1) summary
    cd05293
    Location:20246
    LDH_1; A subgroup of L-lactate dehydrogenases
  2. NM_001316322.1NP_001303251.1  L-lactate dehydrogenase B chain isoform Ldhbx

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (Ldhb) results from translation termination at the upstream UGA stop codon, while the longer isoform (Ldhbx) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (Ldhbx), which is localized in the peroxisomes. As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AK019391, BC046755
    UniProtKB/Swiss-Prot
    P16125
    Related
    ENSMUSP00000159378.2, ENSMUST00000239395.2
    Conserved Domains (2) summary
    cd05293
    Location:20330
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:26326
    L-LDH-NAD; L-lactate dehydrogenase
  3. NM_008492.3NP_032518.1  L-lactate dehydrogenase B chain isoform Ldhb

    See identical proteins and their annotated locations for NP_032518.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (Ldhb) results from translation termination at the upstream UGA stop codon, while the longer isoform (Ldhbx) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (Ldhb), which is localized in the cytosol.
    Source sequence(s)
    AK019391, BC046755
    Consensus CDS
    CCDS20684.1
    UniProtKB/Swiss-Prot
    P16125
    Related
    ENSMUSP00000032373.6, ENSMUST00000032373.12
    Conserved Domains (2) summary
    cd05293
    Location:20330
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:26326
    L-LDH-NAD; L-lactate dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142435975..142453683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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