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Lgals3 lectin, galactose binding, soluble 3 [ Mus musculus (house mouse) ]

Gene ID: 16854, updated on 25-Nov-2021

Summary

Official Symbol
Lgals3provided by MGI
Official Full Name
lectin, galactose binding, soluble 3provided by MGI
Primary source
MGI:MGI:96778
See related
Ensembl:ENSMUSG00000050335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GBP; L-34; gal3; Mac-2
Expression
Biased expression in colon adult (RPKM 931.1), duodenum adult (RPKM 311.5) and 8 other tissues See more
Orthologs
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Genomic context

See Lgals3 in Genome Data Viewer
Location:
14; 14 C1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47611317..47623624)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (47373860..47386167)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (47993535..48005842)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568146 Neighboring gene predicted gene, 52166 Neighboring gene DLG associated protein 5 Neighboring gene ribosomal protein S15 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Fc-gamma receptor I complex binding ISO
Inferred from Sequence Orthology
more info
 
enables IgE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables IgE binding ISO
Inferred from Sequence Orthology
more info
 
enables advanced glycation end-product receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
enables disaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables laminin binding ISO
Inferred from Sequence Orthology
more info
 
enables monosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables oligosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in eosinophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in eosinophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in killing of cells of other organism ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in maintenance of protein location IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in mononuclear cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell proliferation in bone marrow ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of immunological synapse formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mononuclear cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of serotonin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of T cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in glial cell projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in immunological synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
galectin-3
Names
35 kDa lectin
CBP 35
L-34 galactoside-binding lectin
carbohydrate-binding protein 35
gal-3
galactose-specific lectin 3
igE-binding protein
laminin-binding protein
lectin L-29
mac-2 antigen

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145953.1NP_001139425.1  galectin-3

    See identical proteins and their annotated locations for NP_001139425.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC123665, AK149783, BY440035
    Consensus CDS
    CCDS26986.1
    UniProtKB/TrEMBL
    Q8C253
    Related
    ENSMUSP00000114350.2, ENSMUST00000150290.9
    Conserved Domains (2) summary
    smart00908
    Location:137258
    Gal-bind_lectin; Galactoside-binding lectin
    pfam02084
    Location:18110
    Bindin; Bindin
  2. NM_010705.3NP_034835.1  galectin-3

    See identical proteins and their annotated locations for NP_034835.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK149783, BB853044, BY440035
    Consensus CDS
    CCDS26986.1
    UniProtKB/TrEMBL
    Q8C253
    Related
    ENSMUSP00000118169.2, ENSMUST00000142734.8
    Conserved Domains (2) summary
    smart00908
    Location:137258
    Gal-bind_lectin; Galactoside-binding lectin
    pfam02084
    Location:18110
    Bindin; Bindin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    47611317..47623624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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