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Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) [ Mus musculus (house mouse) ]

Gene ID: 16913, updated on 23-Jun-2021

Summary

Official Symbol
Psmb8provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)provided by MGI
Primary source
MGI:MGI:1346527
See related
Ensembl:ENSMUSG00000024338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lm; Lmp; Lmp7; Lmp-7
Expression
Broad expression in thymus adult (RPKM 141.3), large intestine adult (RPKM 117.3) and 15 other tissues See more
Orthologs
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Genomic context

See Psmb8 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34417169..34420428)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34198195..34201454)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34335140..34338399)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) Neighboring gene transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene histocompatibility 2, O region beta locus

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis involved in cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of spermatoproteasome complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome subunit beta type-8
Names
MC13 (LMP7)
large multifunctional protease 7
low molecular mass protein 7
macropain subunit C13
multicatalytic endopeptidase complex subunit C13
proteasome component C13
proteasome subunit MC13
proteasome subunit beta-5i
proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
proteosome beta 8 subunit
NP_034854.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010724.2NP_034854.2  proteasome subunit beta type-8

    See identical proteins and their annotated locations for NP_034854.2

    Status: VALIDATED

    Source sequence(s)
    AK031801, AK150674, CJ235673
    Consensus CDS
    CCDS50073.1
    UniProtKB/Swiss-Prot
    P28063
    Related
    ENSMUSP00000025196.9, ENSMUST00000025196.9
    Conserved Domains (2) summary
    PTZ00488
    Location:40271
    PTZ00488; Proteasome subunit beta type-5; Provisional
    cd03761
    Location:73260
    proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34417169..34420428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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