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ZNF596 zinc finger protein 596 [ Homo sapiens (human) ]

Gene ID: 169270, updated on 11-Jun-2021

Summary

Official Symbol
ZNF596provided by HGNC
Official Full Name
zinc finger protein 596provided by HGNC
Primary source
HGNC:HGNC:27268
See related
Ensembl:ENSG00000172748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 4.6), thyroid (RPKM 1.6) and 23 other tissues See more
Orthologs
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Genomic context

See ZNF596 in Genome Data Viewer
Location:
8p23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (232137..247340)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (182137..197340)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily F member 21 Neighboring gene septin 14 pseudogene 8 Neighboring gene ribosomal protein L23a pseudogene 53 Neighboring gene uncharacterized LOC101927566 Neighboring gene uncharacterized LOC105377773

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36123

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 596
NP_001035880.1
NP_001035881.1
NP_001274183.1
NP_001274184.1
NP_001274185.1
NP_001274328.1
NP_775810.2
XP_011533046.1
XP_016868655.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042415.3NP_001035880.1  zinc finger protein 596 isoform 1

    See identical proteins and their annotated locations for NP_001035880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same isoform (1).
    Source sequence(s)
    AC004908, BC026190, DA504426, DB514599
    Consensus CDS
    CCDS5951.2
    UniProtKB/Swiss-Prot
    Q8TC21
    Conserved Domains (5) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:361502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:434458
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001042416.3NP_001035881.1  zinc finger protein 596 isoform 1

    See identical proteins and their annotated locations for NP_001035881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 6 encode the same isoform (1).
    Source sequence(s)
    AC004908, AK313454, BC026190, DA714658, DB514599
    Consensus CDS
    CCDS5951.2
    UniProtKB/Swiss-Prot
    Q8TC21
    Related
    ENSP00000381613.1, ENST00000398612.3
    Conserved Domains (5) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:361502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:434458
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001287254.2NP_001274183.1  zinc finger protein 596 isoform 1

    See identical proteins and their annotated locations for NP_001274183.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same isoform (1).
    Source sequence(s)
    AC004908, BC026190, DB514599, DR006332
    Consensus CDS
    CCDS5951.2
    UniProtKB/Swiss-Prot
    Q8TC21
    Conserved Domains (5) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:361502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:434458
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001287255.1NP_001274184.1  zinc finger protein 596 isoform 1

    See identical proteins and their annotated locations for NP_001274184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same isoform (1).
    Source sequence(s)
    AC004908, BC026190, DB034950, DB047692, DB055646, DB514599
    Consensus CDS
    CCDS5951.2
    UniProtKB/Swiss-Prot
    Q8TC21
    Related
    ENSP00000318719.3, ENST00000320552.6
    Conserved Domains (5) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:361502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:434458
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001287256.1NP_001274185.1  zinc finger protein 596 isoform 1

    See identical proteins and their annotated locations for NP_001274185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same isoform (1).
    Source sequence(s)
    AC004908, BC026190, DB034950, DB055646, DB514599
    Consensus CDS
    CCDS5951.2
    UniProtKB/Swiss-Prot
    Q8TC21
    Conserved Domains (5) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:361502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:434458
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001287399.1NP_001274328.1  zinc finger protein 596 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC004908, BC026190, BM478564, DB031878, DB053699, DB514599
    UniProtKB/Swiss-Prot
    Q8TC21
    Conserved Domains (3) summary
    COG5048
    Location:228369
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:232252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:301325
    zf-H2C2_2; Zinc-finger double domain
  7. NM_173539.3NP_775810.2  zinc finger protein 596 isoform 1

    See identical proteins and their annotated locations for NP_775810.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 6 encode the same isoform (1).
    Source sequence(s)
    AC004908, AK313454, BC026190, BG771504, DB031878, DB053699, DB514599
    Consensus CDS
    CCDS5951.2
    UniProtKB/Swiss-Prot
    Q8TC21
    Related
    ENSP00000310033.4, ENST00000308811.8
    Conserved Domains (5) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:361502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:434458
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    232137..247340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534744.1XP_011533046.1  zinc finger protein 596 isoform X2

    See identical proteins and their annotated locations for XP_011533046.1

    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:326467
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:330350
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:399423
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017013166.1XP_016868655.1  zinc finger protein 596 isoform X1

    UniProtKB/Swiss-Prot
    Q8TC21
    Conserved Domains (5) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:361502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:434458
    zf-H2C2_2; Zinc-finger double domain
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