Format

Send to:

Choose Destination

Lox lysyl oxidase [ Mus musculus (house mouse) ]

Gene ID: 16948, updated on 20-Jul-2021

Summary

Official Symbol
Loxprovided by MGI
Official Full Name
lysyl oxidaseprovided by MGI
Primary source
MGI:MGI:96817
See related
Ensembl:ENSMUSG00000024529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rrg; TSC-16; TSC-160; AI893619
Summary
This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Expression
Biased expression in limb E14.5 (RPKM 47.6), ovary adult (RPKM 19.3) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Lox in Genome Data Viewer
Location:
18 D1; 18 28.22 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (52649132..52662939, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (52516060..52529867, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (52676892..52689362, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ferritin mitochondrial Neighboring gene serum response factor binding protein 1 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene predicted gene, 41724

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-lysine 6-oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-lysine 6-oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-lysine 6-oxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ascending aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in collagen fibril organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within connective tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within descending aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within elastic fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in elastic fiber assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-lysine oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet-derived growth factor receptor-beta signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein oxidation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of megakaryocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of striated muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in response to steroid hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of collagen trimer IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein-lysine 6-oxidase
Names
ras excision protein
NP_001273110.1
NP_001273111.1
NP_034858.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286181.1NP_001273110.1  protein-lysine 6-oxidase preproprotein

    See identical proteins and their annotated locations for NP_001273110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC161119, AK141995, AK164634, BB840428, BQ033730
    Consensus CDS
    CCDS50289.1
    UniProtKB/Swiss-Prot
    P28301
    UniProtKB/TrEMBL
    Q3TP83, Q3TXH3
    Conserved Domains (2) summary
    PHA03247
    Location:57159
    PHA03247; large tegument protein UL36; Provisional
    pfam01186
    Location:207408
    Lysyl_oxidase; Lysyl oxidase
  2. NM_001286182.1NP_001273111.1  protein-lysine 6-oxidase preproprotein

    See identical proteins and their annotated locations for NP_001273111.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC109203, AK164634, BQ033730
    Consensus CDS
    CCDS50289.1
    UniProtKB/Swiss-Prot
    P28301
    UniProtKB/TrEMBL
    Q3TP83, Q3TXH3
    Related
    ENSMUSP00000129247.2, ENSMUST00000171470.8
    Conserved Domains (2) summary
    PHA03247
    Location:57159
    PHA03247; large tegument protein UL36; Provisional
    pfam01186
    Location:207408
    Lysyl_oxidase; Lysyl oxidase
  3. NM_010728.3NP_034858.2  protein-lysine 6-oxidase preproprotein

    See identical proteins and their annotated locations for NP_034858.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC161119, AK141995, AK164634, BQ033730
    Consensus CDS
    CCDS50289.1
    UniProtKB/Swiss-Prot
    P28301
    UniProtKB/TrEMBL
    Q3TP83, Q3TXH3
    Related
    ENSMUSP00000025409.8, ENSMUST00000025409.9
    Conserved Domains (2) summary
    PHA03247
    Location:57159
    PHA03247; large tegument protein UL36; Provisional
    pfam01186
    Location:207408
    Lysyl_oxidase; Lysyl oxidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    52649132..52662939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center