Lox lysyl oxidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Loxprovided by MGI
Official Full Name: lysyl oxidaseprovided by MGI
Primary source: MGI:MGI:96817
See related: Ensembl:ENSMUSG00000024529 AllianceGenome:MGI:96817
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: rrg; TSC-160
Summary: This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Expression: Biased expression in limb E14.5 (RPKM 47.6), ovary adult (RPKM 19.3) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 D1; 18 28.22 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (52649132..52662939, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (52516060..52529867, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their half-lives and regulates liver fibrosis through Notch signal.
Title: Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their half-lives and regulates liver fibrosis through Notch signal.
Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/beta-catenin via HIF-1a repression in 3T3-L1 cells.
Title: Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/β-catenin via HIF-1a repression in 3T3-L1 cells.
MiR-590-3p Promotes the Phenotypic Switching of Vascular Smooth Muscle Cells by Targeting Lysyl Oxidase.
Title: MiR-590-3p Promotes the Phenotypic Switching of Vascular Smooth Muscle Cells by Targeting Lysyl Oxidase.
Sox6 impairs the adipogenic commitment of mesenchymal stem cells by targeting lysyl oxidase and preadipocyte factor 1.
Title: Sox6 impairs the adipogenic commitment of mesenchymal stem cells by targeting lysyl oxidase and preadipocyte factor 1.
CD11b Deficiency Favors Cartilage Calcification via Increased Matrix Vesicles, Apoptosis, and Lysyl Oxidase Activity.
Title: CD11b Deficiency Favors Cartilage Calcification via Increased Matrix Vesicles, Apoptosis, and Lysyl Oxidase Activity.
The Lysyl Oxidase G473A Polymorphism Exacerbates Oral Cancer Development in Humans and Mice.
Title: The Lysyl Oxidase G473A Polymorphism Exacerbates Oral Cancer Development in Humans and Mice.
Estrogen-related receptor gamma (ERRgamma) is a key regulator of lysyl oxidase gene expression in mouse hepatocytes.
Title: Estrogen-related receptor γ (ERRγ) is a key regulator of lysyl oxidase gene expression in mouse hepatocytes.
Lysyl oxidase regulation and protein aldehydes in the injured newborn lung.
Title: Lysyl oxidase regulation and protein aldehydes in the injured newborn lung.
Inflammation-induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity.
Title: Inflammation-induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity.
Progression and Regression of Abdominal Aortic Aneurysms in Mice.
Title: Progression and Regression of Abdominal Aortic Aneurysms in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (86)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lox (e-PCR), detects polymorphism
- UniSTS:498434

L04262 (e-PCR)
- UniSTS:163603

Lox (e-PCR), detects polymorphism
- UniSTS:546847

D18Mit74 (e-PCR), detects polymorphism
- UniSTS:128289

AI893619 (e-PCR)
- UniSTS:181121

RH134457 (e-PCR)
- UniSTS:217737

PMC153489P3 (e-PCR)
- UniSTS:271256

L04262 (e-PCR)
- UniSTS:124864

Lox (e-PCR), detects polymorphism
- UniSTS:498388

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-lysine 6-oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine 6-oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-lysine 6-oxidase activity	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ascending aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell chemotaxis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to chemokine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to organic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within connective tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within descending aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within elastic fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in elastic fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-lysine oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet-derived growth factor receptor-beta signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within protein oxidation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of megakaryocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of platelet-derived growth factor receptor-beta signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of striated muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in response to steroid hormone	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of collagen trimer	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein-lysine 6-oxidase

Names: ras excision protein

NP_001273110.1

EC 1.4.3.13

NP_001273111.1

EC 1.4.3.13

NP_034858.2

EC 1.4.3.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286181.1 → NP_001273110.1 protein-lysine 6-oxidase preproprotein

See identical proteins and their annotated locations for NP_001273110.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC161119, AK141995, AK164634, BB840428, BQ033730

Consensus CDS

CCDS50289.1

UniProtKB/Swiss-Prot

P28301

UniProtKB/TrEMBL

Q3TLP7, Q3TP83, Q3TWI1, Q3TX90, Q3TXH3

Conserved Domains (2) summary

PHA03247
Location:57 → 159

PHA03247; large tegument protein UL36; Provisional

pfam01186
Location:207 → 408

Lysyl_oxidase; Lysyl oxidase
NM_001286182.1 → NP_001273111.1 protein-lysine 6-oxidase preproprotein

See identical proteins and their annotated locations for NP_001273111.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC109203, AK164634, BQ033730

Consensus CDS

CCDS50289.1

UniProtKB/Swiss-Prot

P28301

UniProtKB/TrEMBL

Q3TLP7, Q3TP83, Q3TWI1, Q3TX90, Q3TXH3

Related

ENSMUSP00000129247.2, ENSMUST00000171470.8

Conserved Domains (2) summary

PHA03247
Location:57 → 159

PHA03247; large tegument protein UL36; Provisional

pfam01186
Location:207 → 408

Lysyl_oxidase; Lysyl oxidase
NM_010728.4 → NP_034858.2 protein-lysine 6-oxidase preproprotein

See identical proteins and their annotated locations for NP_034858.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC109203, AC161119

Consensus CDS

CCDS50289.1

UniProtKB/Swiss-Prot

P28301

UniProtKB/TrEMBL

Q3TLP7, Q3TP83, Q3TWI1, Q3TX90, Q3TXH3

Related

ENSMUSP00000025409.8, ENSMUST00000025409.9

Conserved Domains (2) summary

PHA03247
Location:57 → 159

PHA03247; large tegument protein UL36; Provisional

pfam01186
Location:207 → 408

Lysyl_oxidase; Lysyl oxidase