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Lrrn1 leucine rich repeat protein 1, neuronal [ Mus musculus (house mouse) ]

Gene ID: 16979, updated on 21-Apr-2024

Summary

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Official Symbol
Lrrn1provided by MGI
Official Full Name
leucine rich repeat protein 1, neuronalprovided by MGI
Primary source
MGI:MGI:106038
See related
Ensembl:ENSMUSG00000034648 AllianceGenome:MGI:106038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NLRR-1; 2810047E21Rik
Summary
Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including central nervous system; dorsal root ganglion; embryo mesenchyme; lip; and sensory organ. Orthologous to human LRRN1 (leucine rich repeat neuronal 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 59.2), ovary adult (RPKM 34.4) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E1; 6 49.71 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (107506687..107547189)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (107529726..107570228)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16942 Neighboring gene peptidylprolyl isomerase A pseudogene 6_1128.1 Neighboring gene STARR-seq mESC enhancer starr_16943 Neighboring gene STARR-seq mESC enhancer starr_16944 Neighboring gene predicted gene, 34933 Neighboring gene STARR-seq mESC enhancer starr_16945 Neighboring gene STARR-seq mESC enhancer starr_16946 Neighboring gene STARR-seq mESC enhancer starr_16947 Neighboring gene predicted gene, 35017 Neighboring gene vomeronasal 1 receptor, pseudogene 37

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Taguchi A, et al. Brain Res Mol Brain Res, 1996 Jan. PMID 8717337
  2. Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma. Satoh S, et al. Sci Rep, 2016 Sep 8. PMID 27604320, Free PMC Article
  3. Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Aubert J, et al. Proc Natl Acad Sci U S A, 2003 Sep 30. PMID 12923295, Free PMC Article
  4. The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts. Haines BP, et al. Dev Biol, 2005 May 15. PMID 15893969
  5. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Gobert RP, et al. Mol Cell Biol, 2009 Mar. PMID 19139271, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti.
    Title: Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti.
  2. NLRR1 appears to be an extracellular negative regulator of ALK signalling in neuroblastoma and neuronal development.
    Title: Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma.
  3. NLRR-1 is expressed in a subset of myotome cells.
    Title: The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat neuronal protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008516.4 → NP_032542.1  leucine-rich repeat neuronal protein 1 precursor

    See identical proteins and their annotated locations for NP_032542.1

    Status: VALIDATED

    Source sequence(s)
    AC155327, AK139965, AK160841
    Consensus CDS
    CCDS20399.1
    UniProtKB/Swiss-Prot
    Q3USY1, Q61809, Q69ZI0
    Related
    ENSMUSP00000037096.9, ENSMUST00000049285.10
    Conserved Domains (8) summary
    smart00082
    Location:371 → 419
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:11 → 273
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:429 → 516
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:339 → 362
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:97 → 120
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:531 → 600
    fn3; Fibronectin type III domain
    pfam13855
    Location:119 → 179
    LRR_8; Leucine rich repeat
    cl11960
    Location:431 → 516
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    107506687..107547189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61809.1 GenPept UniProtKB/Swiss-Prot:Q61809

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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