Format

Send to:

Choose Destination

ZNF169 zinc finger protein 169 [ Homo sapiens (human) ]

Gene ID: 169841, updated on 11-Jun-2021

Summary

Official Symbol
ZNF169provided by HGNC
Official Full Name
zinc finger protein 169provided by HGNC
Primary source
HGNC:HGNC:12957
See related
Ensembl:ENSG00000175787 MIM:603404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF169 in Genome Data Viewer
Location:
9q22.32
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (94259298..94303967)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (97021580..97064111)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene miRlet-7a-1/let-7f-1/let-7d cluster host gene Neighboring gene microRNA let-7f-1 Neighboring gene long intergenic non-protein coding RNA 2603 Neighboring gene microRNA let-7d Neighboring gene voltage dependent anion channel 1 pseudogene 11 Neighboring gene uncharacterized LOC105376154 Neighboring gene uncharacterized LOC100132077 Neighboring gene NUT family member 2F Neighboring gene proline-rich nuclear receptor coactivator 2-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC51961

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301275.2NP_001288204.1  zinc finger protein 169 isoform 3

    See identical proteins and their annotated locations for NP_001288204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK093956, AL691447, HY115642
    Conserved Domains (3) summary
    COG5048
    Location:31392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:4565
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:5782
    zf-H2C2_2; Zinc-finger double domain
  2. NM_003448.3NP_003439.2  zinc finger protein 169 isoform 1

    See identical proteins and their annotated locations for NP_003439.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL691447, DA490480, HY115642
    Conserved Domains (6) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:223584
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:237257
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:235257
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:249274
    zf-H2C2_2; Zinc-finger double domain
  3. NM_194320.4NP_919301.2  zinc finger protein 169 isoform 2

    See identical proteins and their annotated locations for NP_919301.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL691447, BC047702, HY115642
    Consensus CDS
    CCDS6709.2
    UniProtKB/Swiss-Prot
    Q14929
    Related
    ENSP00000378792.2, ENST00000395395.7
    Conserved Domains (3) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:222595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236256
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    94259298..94303967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014364.1XP_016869853.1  zinc finger protein 169 isoform X2

    UniProtKB/Swiss-Prot
    Q14929
    Conserved Domains (3) summary
    smart00349
    Location:160
    KRAB; krueppel associated box
    COG5048
    Location:209570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223243
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_024447432.1XP_024303200.1  zinc finger protein 169 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:222595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236256
    ZF_C2H2; C2H2 Zn finger [structural motif]
Support Center