U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF169 zinc finger protein 169 [ Homo sapiens (human) ]

Gene ID: 169841, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF169provided by HGNC
Official Full Name
zinc finger protein 169provided by HGNC
Primary source
HGNC:HGNC:12957
See related
Ensembl:ENSG00000175787 MIM:603404; AllianceGenome:HGNC:12957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9q22.32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (94259298..94301829)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (106427373..106469821)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (97021580..97064111)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2603 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124902332 Neighboring gene NANOG hESC enhancer GRCh37_chr9:97012845-97013355 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr9:97021099-97021744 and GRCh37_chr9:97021745-97022391 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97022392-97023037 Neighboring gene NANOG hESC enhancer GRCh37_chr9:97044568-97045069 Neighboring gene voltage dependent anion channel 1 pseudogene 11 Neighboring gene uncharacterized LOC105376154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97080767-97081446 Neighboring gene uncharacterized LOC124902217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20055 Neighboring gene uncharacterized LOC100132077 Neighboring gene NUT family member 2F

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A YAC-based transcript map of human chromosome 9q22.1-q22.3 encompassing the loci for hereditary sensory neuropathy type I and multiple self-healing squamous epithelioma. Blair IP, et al. Genomics, 1998 Jul 15. PMID 9722951
  2. Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: placement of a novel zinc finger gene within the NBCCS and ESS1 region. Levanat S, et al. Cytogenet Cell Genet, 1997. PMID 9186526
  3. Characterization of a YAC contig containing the NBCCS locus and a novel Kruppel-type zinc finger sequence on chromosome segment 9q22.3. Chidambaram A, et al. Genes Chromosomes Cancer, 1997 Mar. PMID 9071574
  4. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Okada Y, et al. Nat Genet, 2012 Feb 19. PMID 22344221, Free PMC Article
  5. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. Bhattacharya S, et al. Cell Oncol (Dordr), 2015 Aug. PMID 25925205

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC51961

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 169

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301275.2 → NP_001288204.1  zinc finger protein 169 isoform 3

    See identical proteins and their annotated locations for NP_001288204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK093956, AL691447, HY115642
    Conserved Domains (3) summary
    COG5048
    Location:31 → 392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:45 → 65
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:57 → 82
    zf-H2C2_2; Zinc-finger double domain

  2. NM_003448.3 → NP_003439.2  zinc finger protein 169 isoform 1

    See identical proteins and their annotated locations for NP_003439.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL691447, DA490480, HY115642
    Conserved Domains (6) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:223 → 584
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:237 → 257
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:235 → 257
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:249 → 274
    zf-H2C2_2; Zinc-finger double domain

  3. NM_194320.4 → NP_919301.2  zinc finger protein 169 isoform 2

    See identical proteins and their annotated locations for NP_919301.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL691447, BC047702, HY115642
    Consensus CDS
    CCDS6709.2
    UniProtKB/Swiss-Prot
    A2AGP5, A8K127, Q14929, Q6PI28
    Related
    ENSP00000378792.2, ENST00000395395.7
    Conserved Domains (3) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:222 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236 → 256
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    94259298..94301829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447432.2 → XP_024303200.1  zinc finger protein 169 isoform X1

    UniProtKB/Swiss-Prot
    A2AGP5, A8K127, Q14929, Q6PI28
    Conserved Domains (3) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:222 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236 → 256
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_017014364.2 → XP_016869853.1  zinc finger protein 169 isoform X2

    UniProtKB/Swiss-Prot
    Q14929
    Conserved Domains (3) summary
    smart00349
    Location:1 → 60
    KRAB; krueppel associated box
    COG5048
    Location:209 → 570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 243
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    106427373..106469821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362219.1 → XP_054218194.1  zinc finger protein 169 isoform X1

  2. XM_054362220.1 → XP_054218195.1  zinc finger protein 169 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14929.3 GenPept UniProtKB/Swiss-Prot:Q14929

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous