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Lss lanosterol synthase [ Mus musculus (house mouse) ]

Gene ID: 16987, updated on 23-Jun-2021

Summary

Official Symbol
Lssprovided by MGI
Official Full Name
lanosterol synthaseprovided by MGI
Primary source
MGI:MGI:1336155
See related
Ensembl:ENSMUSG00000033105
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
O; Osc; D10Ertd116; D10Ertd116e; 2810025N20Rik
Summary
This gene encodes an enzyme that catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in liver E18 (RPKM 29.4), liver E14.5 (RPKM 13.5) and 27 other tissues See more
Orthologs
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Genomic context

See Lss in Genome Data Viewer
Location:
10 C1; 10 39.1 cM
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76367303..76392973)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76531565..76557139)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75994372..76016679)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610028H24 gene Neighboring gene ybeY metallopeptidase Neighboring gene minichromosome maintenance complex component 3 associated protein Neighboring gene RIKEN cDNA 4930483K19 gene Neighboring gene spermatogenesis and centriole associated 1 like Neighboring gene predicted gene 15343 Neighboring gene formiminotransferase cyclodeaminase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27893

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-amyrin synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables intramolecular transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables lanosterol synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lanosterol synthase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in triterpenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lanosterol synthase
Names
2,3-epoxysqualene--lanosterol cyclase
oxidosqualene--lanosterol cyclase
NP_666118.1
XP_006513347.1
XP_030100782.1
XP_036011544.1
XP_036011545.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146006.2NP_666118.1  lanosterol synthase

    See identical proteins and their annotated locations for NP_666118.1

    Status: REVIEWED

    Source sequence(s)
    AK014742, AK031271, AK078023, AK141216, AK147680, BY474863, CJ128932
    Consensus CDS
    CCDS23948.1
    UniProtKB/Swiss-Prot
    Q8BLN5
    Related
    ENSMUSP00000046856.7, ENSMUST00000048678.7
    Conserved Domains (2) summary
    cd02892
    Location:78720
    SQCY_1; Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization ...
    TIGR01787
    Location:77722
    squalene_cyclas; squalene/oxidosqualene cyclases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    76367303..76392973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155651.1XP_036011544.1  lanosterol synthase isoform X1

    Conserved Domains (1) summary
    TIGR01787
    Location:1595
    squalene_cyclas; squalene/oxidosqualene cyclases
  2. XM_006513284.4XP_006513347.1  lanosterol synthase isoform X2

    Conserved Domains (1) summary
    TIGR01787
    Location:77523
    squalene_cyclas; squalene/oxidosqualene cyclases
  3. XM_036155652.1XP_036011545.1  lanosterol synthase isoform X3

    Conserved Domains (1) summary
    TIGR01787
    Location:1507
    squalene_cyclas; squalene/oxidosqualene cyclases
  4. XM_030244922.2XP_030100782.1  lanosterol synthase isoform X3

    Related
    ENSMUST00000160671.8
    Conserved Domains (1) summary
    TIGR01787
    Location:1507
    squalene_cyclas; squalene/oxidosqualene cyclases

RNA

  1. XR_004936110.1 RNA Sequence

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