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Ltk leukocyte tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 17005, updated on 23-Jun-2021

Summary

Official Symbol
Ltkprovided by MGI
Official Full Name
leukocyte tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:96840
See related
Ensembl:ENSMUSG00000027297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons. [provided by RefSeq, Jul 2008]
Expression
Broad expression in cortex adult (RPKM 11.7), frontal lobe adult (RPKM 7.9) and 15 other tissues See more
Orthologs
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Genomic context

See Ltk in Genome Data Viewer
Location:
2 E5; 2 59.97 cM
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119581807..119590912, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119751326..119760431, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (119577062..119586167, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25857 Neighboring gene inositol 1,4,5-trisphosphate 3-kinase A Neighboring gene RNA polymerase II associated protein 1 Neighboring gene predicted gene, 23814

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
leukocyte tyrosine kinase receptor
Names
leukocyte receptor tyrosine kinase
NP_032549.2
NP_976220.2
NP_996824.1
NP_996825.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008523.2NP_032549.2  leukocyte tyrosine kinase receptor isoform A

    See identical proteins and their annotated locations for NP_032549.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is lacking several exons from the 5' end, and an internal coding exon compared to transcript variant 4. This results in a shorter isoform (A), which has a different N-terminus, is missing a 61 aa segment compared to isoform D, and that is localized in the endoplasmic reticulum. This variant is specifically expressed in the lymphocytes and initiates translation from a non-AUG (CUG) start codon.
    Source sequence(s)
    BC047138
    Consensus CDS
    CCDS50674.1
    UniProtKB/TrEMBL
    Q0VGZ5
    Related
    ENSMUSP00000138201.3, ENSMUST00000182203.3
    Conserved Domains (2) summary
    cd05036
    Location:187463
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
    pfam07714
    Location:194461
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_203345.2NP_976220.2  leukocyte tyrosine kinase receptor isoform D precursor

    See identical proteins and their annotated locations for NP_976220.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (D), is expressed in neuroblastoma cells, and initiates translation from the standard AUG start codon.
    Source sequence(s)
    AL844536, BC047138, M90470
    Consensus CDS
    CCDS16608.1
    UniProtKB/Swiss-Prot
    P08923
    UniProtKB/TrEMBL
    Q0VGZ5
    Related
    ENSMUSP00000028759.7, ENSMUST00000028759.13
    Conserved Domains (2) summary
    cd05036
    Location:499775
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
    pfam07714
    Location:506773
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_206941.1NP_996824.1  leukocyte tyrosine kinase receptor isoform B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing several exons from the 5' end, and has a different 5' end exon compared to transcript variant 4. This results in a shorter isoform (B) with a different N-terminus compared to isoform D. This variant is specifically expressed in the brain and initiates translation from a non-AUG (CUG) start codon.
    Source sequence(s)
    BC047138, M90470
    UniProtKB/Swiss-Prot
    P08923
    UniProtKB/TrEMBL
    Q0VGZ5
    Conserved Domains (2) summary
    cd05036
    Location:248524
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
    pfam07714
    Location:255522
    Pkinase_Tyr; Protein tyrosine kinase
  4. NM_206942.2NP_996825.2  leukocyte tyrosine kinase receptor isoform C precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is lacking an internal coding exon compared to transcript variant 4. This results in an isoform (C), which is missing a 61 aa segment compared to isoform D, and that is localized in the endoplasmic reticulum. This variant is expressed in neuroblastoma cells and initiates translation from the standard AUG start codon.
    Source sequence(s)
    AL844536, BC047138, M90470
    Consensus CDS
    CCDS16609.1
    UniProtKB/Swiss-Prot
    P08923
    UniProtKB/TrEMBL
    Q0VGZ5
    Related
    ENSMUSP00000080774.7, ENSMUST00000082130.13
    Conserved Domains (2) summary
    cd05036
    Location:438714
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
    pfam07714
    Location:445712
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119581807..119590912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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