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TCEANC transcription elongation factor A N-terminal and central domain containing [ Homo sapiens (human) ]

Gene ID: 170082, updated on 7-Apr-2024

Summary

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Official Symbol
TCEANCprovided by HGNC
Official Full Name
transcription elongation factor A N-terminal and central domain containingprovided by HGNC
Primary source
HGNC:HGNC:28277
See related
Ensembl:ENSG00000176896 MIM:301084; AllianceGenome:HGNC:28277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCEANC1
Summary
Predicted to be involved in transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 1.6), thyroid (RPKM 1.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
Xp22.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (13653141..13665409)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (13234528..13246800)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (13671260..13683528)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene EGF like domain multiple 6 Neighboring gene microRNA 6086 Neighboring gene RN7SK pseudogene 20 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:13630114-13630666 Neighboring gene NANOG hESC enhancer GRCh37_chrX:13638269-13638787 Neighboring gene uncharacterized LOC107985657 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:13671061-13671372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29442 Neighboring gene uncharacterized LOC107985656 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:13687079-13688278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20668 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:13710181-13710377 Neighboring gene RAB9A, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Rapid identification of 14-3-3-binding proteins by protein microarray analysis. Satoh J, et al. J Neurosci Methods, 2006 Apr 15. PMID 16260042
  2. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. Teixeira FR, et al. J Biol Chem, 2013 Sep 27. PMID 23940030, Free PMC Article
  3. Expanding the substantial interactome of NEMO using protein microarrays. Fenner BJ, et al. PLoS One, 2010 Jan 20. PMID 20098747, Free PMC Article
  4. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Hill SJ, et al. Genes Dev, 2014 Sep 1. PMID 25184681, Free PMC Article
  5. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC17403

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription elongation factor A N-terminal and central domain-containing protein
Names
TFIIS central domain-containing protein 1
TFS2-M domain-containing protein 1
transcription elongation factor A (SII) N-terminal and central domain containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297563.2 → NP_001284492.1  transcription elongation factor A N-terminal and central domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_001284492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional exon in the 5' UTR which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC079383, AK291271, BC020095
    Consensus CDS
    CCDS75954.1
    UniProtKB/Swiss-Prot
    A6NI06, B2RDM3, Q8N8B7
    UniProtKB/TrEMBL
    A0A8Q3SID2
    Related
    ENSP00000512421.1, ENST00000696128.1
    Conserved Domains (4) summary
    TIGR01385
    Location:6 → 343
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:172 → 278
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam08711
    Location:29 → 78
    Med26; TFIIS helical bundle-like domain
    cl02609
    Location:289 → 343
    Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

  2. NM_001297564.2 → NP_001284493.1  transcription elongation factor A N-terminal and central domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_001284493.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR and coding region which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC079383, AK315599, BC020095
    Consensus CDS
    CCDS75954.1
    UniProtKB/Swiss-Prot
    A6NI06, B2RDM3, Q8N8B7
    UniProtKB/TrEMBL
    A0A8Q3SID2
    Related
    ENSP00000369974.1, ENST00000380600.2
    Conserved Domains (4) summary
    TIGR01385
    Location:6 → 343
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:172 → 278
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam08711
    Location:29 → 78
    Med26; TFIIS helical bundle-like domain
    cl02609
    Location:289 → 343
    Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

  3. NM_152634.4 → NP_689847.2  transcription elongation factor A N-terminal and central domain-containing protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC079383, AK294465, BC020095
    Consensus CDS
    CCDS48081.1
    UniProtKB/TrEMBL
    B4DG85
    Related
    ENSP00000440038.2, ENST00000544987.3
    Conserved Domains (4) summary
    TIGR01385
    Location:36 → 373
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:202 → 308
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam08711
    Location:59 → 108
    Med26; TFIIS helical bundle-like domain
    cl02609
    Location:319 → 373
    Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    13653141..13665409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029316.2 → XP_016884805.1  transcription elongation factor A N-terminal and central domain-containing protein isoform X1

    UniProtKB/TrEMBL
    B4DG85
    Conserved Domains (4) summary
    TIGR01385
    Location:36 → 373
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:202 → 308
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam08711
    Location:59 → 108
    Med26; TFIIS helical bundle-like domain
    cl02609
    Location:319 → 373
    Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    13234528..13246800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326596.1 → XP_054182571.1  transcription elongation factor A N-terminal and central domain-containing protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N8B7.2 GenPept UniProtKB/Swiss-Prot:Q8N8B7

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