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Ryr3 ryanodine receptor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170546, updated on 11-Apr-2024

Summary

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Official Symbol
Ryr3provided by RGD
Official Full Name
ryanodine receptor 3provided by RGD
Primary source
RGD:68952
See related
Ensembl:ENSRNOG00000006645 AllianceGenome:RGD:68952
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium-induced calcium release activity and ryanodine-sensitive calcium-release channel activity. Involved in negative regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum and perinuclear region of cytoplasm. Orthologous to human RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 73.2), Heart (RPKM 54.6) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ryr3 in Genome Data Viewer
Location:
3q35
Exon count:
105
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (119886129..120433465, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (99431755..99979125, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (104117307..104665151, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene apoptosis and caspase activation inhibitor Neighboring gene proteasome subunit beta type-3-like Neighboring gene large ribosomal subunit protein eL30-like Neighboring gene uncharacterized LOC120101913 Neighboring gene uncharacterized LOC108350585 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120101454 Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A polymorphism at the microRNA binding site in the 3' untranslated region of RYR3 is associated with outcome in hepatocellular carcinoma. Peng C, et al. Onco Targets Ther, 2015. PMID 26309413, Free PMC Article
  2. Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex. Bull R, et al. Am J Physiol Cell Physiol, 2007 Jul. PMID 17360812
  3. Advancing age alters the expression of the ryanodine receptor 3 isoform in adult rat superior cervical ganglia. Vanterpool CK, et al. J Appl Physiol (1985), 2006 Aug. PMID 16645194, Free PMC Article
  4. Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells. Zheng YM, et al. J Gen Physiol, 2005 Apr. PMID 15795312, Free PMC Article
  5. Contribution of ryanodine receptor subtype 3 to ca2+ responses in Ca2+-overloaded cultured rat portal vein myocytes. Mironneau J, et al. J Biol Chem, 2001 Apr 6. PMID 11150292

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform.
    Title: Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform.
  2. Expression levels of dihydropyridine alpha1c and RyR3 receptors in the rat diaphragm are unaffected during sepsis.
    Title: Reduced DHPRα1S and RyR1 expression levels are associated with diaphragm contractile dysfunction during sepsis.
  3. In endoplasmic reticulum from brain cortex channel redox state determines RyR activation by Ca(2+) at physiological [ATP] and [Mg(2+)].
    Title: Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex.
  4. In PASMCs from RyR3 knockout mice, hypoxia-induced, but not submaximal noradrenaline-induced, Ca2+ release and contraction were significantly reduced.
    Title: Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells.
  5. These data suggest that advancing age selectively impacts the genetic expression and protein levels of RyR3 as well as modulatory nNOS protein levels. The function of RyRs may occur with the normal aging process.
    Title: Advancing age alters the expression of the ryanodine receptor 3 isoform in adult rat superior cervical ganglia.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-induced calcium release activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellularly gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables ryanodine-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in striated muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within striated muscle contraction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of junctional membrane complex ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in smooth endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ryanodine receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    119886129..120433465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284953.1 → XP_063141023.1  ryanodine receptor 3 isoform X6

  2. XM_063284952.1 → XP_063141022.1  ryanodine receptor 3 isoform X5

  3. XM_063284951.1 → XP_063141021.1  ryanodine receptor 3 isoform X4

  4. XM_063284950.1 → XP_063141020.1  ryanodine receptor 3 isoform X3

  5. XM_063284955.1 → XP_063141025.1  ryanodine receptor 3 isoform X8

  6. XM_063284949.1 → XP_063141019.1  ryanodine receptor 3 isoform X2

  7. XM_063284954.1 → XP_063141024.1  ryanodine receptor 3 isoform X7

  8. XM_063284948.1 → XP_063141018.1  ryanodine receptor 3 isoform X1

  9. XM_063284956.1 → XP_063141026.1  ryanodine receptor 3 isoform X9

  10. XM_063284957.1 → XP_063141027.1  ryanodine receptor 3 isoform X10

  11. XM_063284958.1 → XP_063141028.1  ryanodine receptor 3 isoform X11

  12. XM_063284959.1 → XP_063141029.1  ryanodine receptor 3 isoform X12

RNA

  1. XR_010064867.1 RNA Sequence

  2. XR_010064868.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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