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Slc38a4 solute carrier family 38, member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170573, updated on 11-Apr-2024

Summary

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Official Symbol
Slc38a4provided by RGD
Official Full Name
solute carrier family 38, member 4provided by RGD
Primary source
RGD:621836
See related
Ensembl:ENSRNOG00000006653 AllianceGenome:RGD:621836
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ata3
Summary
Enables amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be integral component of plasma membrane. Orthologous to human SLC38A4 (solute carrier family 38 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1589.5) and Muscle (RPKM 275.4) See more
Orthologs
human mouse all
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Genomic context

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Location:
7q35
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (130022039..130082169, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (128142866..128203000, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (138459576..138512952, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene proline-rich basic protein 1, pseudogene 2 Neighboring gene uncharacterized LOC108351545 Neighboring gene uncharacterized LOC120093722 Neighboring gene uncharacterized LOC108351546 Neighboring gene uncharacterized LOC120093723 Neighboring gene uncharacterized LOC120093724

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Sugawara M, et al. Biochim Biophys Acta, 2000 Dec 20. PMID 11118514
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-arginine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-arginine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alanine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables alanine:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neutral L-amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in L-alanine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-alanine import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in L-alanine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-alanine transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-arginine transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium-coupled neutral amino acid transporter 4
Names
Na(+)-coupled neutral amino acid transporter 4
amino acid transport system A3
amino acid transporter A3
system A amino acid transporter 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130748.1 → NP_570104.1  sodium-coupled neutral amino acid transporter 4

    See identical proteins and their annotated locations for NP_570104.1

    Status: PROVISIONAL

    Source sequence(s)
    AF295535
    UniProtKB/Swiss-Prot
    Q9EQ25
    UniProtKB/TrEMBL
    A6KC31
    Related
    ENSRNOP00000009187.2, ENSRNOT00000009187.6
    Conserved Domains (1) summary
    cl00456
    Location:73 → 535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    130022039..130082169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078322.1 → XP_038934250.1  sodium-coupled neutral amino acid transporter 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQ25
    UniProtKB/TrEMBL
    A6KC31
    Conserved Domains (1) summary
    cl00456
    Location:73 → 535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_008765663.3 → XP_008763885.1  sodium-coupled neutral amino acid transporter 4 isoform X1

    See identical proteins and their annotated locations for XP_008763885.1

    UniProtKB/Swiss-Prot
    Q9EQ25
    UniProtKB/TrEMBL
    A6KC31
    Conserved Domains (1) summary
    cl00456
    Location:73 → 535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQ25.1 GenPept UniProtKB/Swiss-Prot:Q9EQ25

Gene LinkOut

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