Cd93 CD93 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd93provided by MGI
Official Full Name: CD93 antigenprovided by MGI
Primary source: MGI:MGI:106664
See related: Ensembl:ENSMUSG00000027435 AllianceGenome:MGI:106664
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly68; AA4.1; C1qr1; C1qrp; 6030404G09Rik
Summary: Predicted to enable complement component C1q complex binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Located in cell surface; cytoplasmic vesicle; and plasma membrane. Is expressed in blood vessel. Orthologous to human CD93 (CD93 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 38.3), subcutaneous fat pad adult (RPKM 17.9) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 73.48 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (148278571..148285455, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (148436651..148443535, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD93 maintains endothelial barrier function and limits metastatic dissemination.
Title: CD93 maintains endothelial barrier function and limits metastatic dissemination.
Structural insight into CD93 recognition by IGFBP7.
Title: Structural insight into CD93 recognition by IGFBP7.
The C-Type Lectin Receptor CD93 Regulates Platelet Activation and Surface Expression of the Protease Activated Receptor 4.
Title: The C-Type Lectin Receptor CD93 Regulates Platelet Activation and Surface Expression of the Protease Activated Receptor 4.
CD93 maintains endothelial barrier function by limiting the phosphorylation and turnover of VE-cadherin.
Title: CD93 maintains endothelial barrier function by limiting the phosphorylation and turnover of VE-cadherin.
Hypomethylation of C1q/tumor necrosis factor-related protein-1 promoter region in whole blood and risks for coronary artery aneurysms in Kawasaki disease.
Title: Hypomethylation of C1q/tumor necrosis factor-related protein-1 promoter region in whole blood and risks for coronary artery aneurysms in Kawasaki disease.
These results reveal that CD93 is a negative regulator of the onset of astrogenesis and provide insight into therapy for psychiatric disorders.
Title: CD93 negatively regulates astrogenesis in response to MMRN2 through the transcriptional repressor ZFP503 in the developing brain.
These findings demonstrate a key role of CD93 in vascular maturation and organization of the extracellular matrix in tumors, identifying it as a potential target for therapy.
Title: CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis.
CD93 is an important neuro-immune regulator to control central nervous system inflammation.
Title: CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis.
serum CD93 is a biomarker for allergic asthma
Title: Potential of serum soluble CD93 as a biomarker for asthma in an ovalbumin-induced asthma murine model.
The expression of cd93 was observed in pancreatic islets, and leaky vessels were apparent in cd93-deficient pancreases. We further demonstrated that stress-induced release of sCD93 is impaired by hyperglycemia. Study propose CD93 as an important component in glucometabolic regulation.
Title: Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (6)

General gene information

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Markers

Ly68 (e-PCR), detects polymorphism
- UniSTS:226141

AW555904 (e-PCR)
- UniSTS:185503

RH137518 (e-PCR)
- UniSTS:219606

AF081789 (e-PCR)
- UniSTS:163300

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables complement component C1q complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement component C1q receptor

Names: C1q/MBL/SPA receptor; C1qR(p); cell surface antigen AA4; complement component 1, q subcomponent, receptor 1; ly-68; lymphocyte antigen 68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010740.3 → NP_034870.1 complement component C1q receptor precursor

See identical proteins and their annotated locations for NP_034870.1

Status: PROVISIONAL

Source sequence(s)

AK079060, AL935149

Consensus CDS

CCDS16839.1

UniProtKB/Swiss-Prot

A2AVY5, O89103, Q3U2X0

Related

ENSMUSP00000096876.4, ENSMUST00000099269.4

Conserved Domains (6) summary

smart00179
Location:424 → 456

EGF_CA; Calcium-binding EGF-like domain

pfam00008
Location:303 → 331

EGF; EGF-like domain

pfam12662
Location:323 → 345

cEGF; Complement Clr-like EGF-like

pfam14670
Location:261 → 297

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:376 → 419

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

cl02432
Location:30 → 183

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain