Slco1a4 solute carrier organic anion transporter family, member 1a4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slco1a4provided by RGD
Official Full Name: solute carrier organic anion transporter family, member 1a4provided by RGD
Primary source: RGD:621389
See related: Ensembl:ENSRNOG00000047493 AllianceGenome:RGD:621389
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oatp2; Slc21a5; Slco1a2
Summary: Enables bile acid transmembrane transporter activity and organic anion transmembrane transporter activity. Involved in several processes, including bile acid signaling pathway; organic anion transport; and response to 17alpha-ethynylestradiol. Located in basal plasma membrane. Biomarker of Dubin-Johnson syndrome; cholestasis; and fatty liver disease. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1024.6) and Brain (RPKM 150.3) See more
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Genomic context

Location:: 4q44

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (176441104..176495846, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (174710004..174764810, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (175969549..176026227, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2.
Title: miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2.
Organic anion transporting polypeptide 1A2 mediates fentanyl uptake in cultured cells.
Title: Organic anion transporting polypeptide 1A2 mediates fentanyl uptake in cultured cells.
optimal rOATP1A4 trafficking to the cell surface is dependent upon coexpression and interaction with rOATP1A1.
Title: Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation and Trafficking to the Hepatocyte Plasma Membrane.
Oatp1a4 appears to play a major role in Cerebrospinal Fluid detoxification by limiting the distribution of organic anions to the brain and spinal cord.
Title: Organic Anion-Transporting Polypeptide 1a4 (Oatp1a4/Slco1a4) at the Blood-Arachnoid Barrier is the Major Pathway of Sulforhodamine-101 Clearance from Cerebrospinal Fluid of Rats.
The Oatp1a4 function is dominant in the region around the hepatic CV in rat hepatic lobules.
Title: Organic anion-transporting polypeptide 1a4-mediated heterogeneous distribution of sulforhodamine-101 in rat hepatic lobules.
Oatp1a4 transport activity at the BBB is directly regulated by TGF-beta/ALK1 signaling.
Title: Functional Expression of Organic Anion Transporting Polypeptide 1a4 Is Regulated by Transforming Growth Factor-β/Activin Receptor-like Kinase 1 Signaling at the Blood-Brain Barrier.
Study finds sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood-brain barrier in Sprague-Dawley rats.
Title: Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood-brain barrier in Sprague-Dawley rats.
Upon chronic/sub-chronic loss of bile excretion, rocuronium clearance via the kidneys is enhanced, by Oatp2 up-regulation.
Title: Increased Renal Clearance of Rocuronium Compensates for Chronic Loss of Bile Excretion, via upregulation of Oatp2.
This study demostrated that transport of VPA is mediated by Oatp2. Oatp2 may play an important role in influencing the pharmacological activity of VPA by affecting its uptake and distribution in the brain.
Title: Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells.
These findings suggest the possibility that ABCC2-mediated hepatobiliary excretion and OATP1/OATP2-mediated hepatic uptake do not play important roles in the disposition of regorafenib.
Title: Lack of Contribution of Multidrug Resistance-associated Protein and Organic Anion-transporting Polypeptide to Pharmacokinetics of Regorafenib, a Novel Multi-Kinase Inhibitor, in Rats.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Markers

D4Rat86 (e-PCR)
- UniSTS:118878

RH130074 (e-PCR)
- UniSTS:213362

AU046939 (e-PCR)
- UniSTS:110998

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in bile acid signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of bile acid secretion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium-independent organic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 1A4

Names: OATP-B1; brain digoxin carrier protein; brain-specific organic anion transporter; organic anion transporter 2; sodium-independent organic anion-transporting polypeptide 2; solute carrier family 21 (organic anion transporter), member 5; solute carrier family 21 member 5; solute carrier organic anion transporter family, member 1A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.