Tlr7 toll-like receptor 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlr7provided by MGI
Official Full Name: toll-like receptor 7provided by MGI
Primary source: MGI:MGI:2176882
See related: Ensembl:ENSMUSG00000044583 AllianceGenome:MGI:2176882
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables siRNA binding activity and single-stranded RNA binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; response to virus; and toll-like receptor 7 signaling pathway. Acts upstream of or within positive regulation of interleukin-6 production and regulation of protein phosphorylation. Located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Is expressed in brain and liver. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: X F5; X 78.31 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (166086376..166113570, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (167303380..167330574, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MDSC-derived S100A8/9 contributes to lupus pathogenesis by promoting TLR7-mediated activation of macrophages and dendritic cells.
Title: MDSC-derived S100A8/9 contributes to lupus pathogenesis by promoting TLR7-mediated activation of macrophages and dendritic cells.
Toll-like receptor 7 and tumor necrosis factor alpha polymorphisms in Egyptian patients with autoimmune thyroid diseases.
Title: Toll-like receptor 7 and tumor necrosis factor alpha polymorphisms in Egyptian patients with autoimmune thyroid diseases.
TLR7 activation of age-associated B cells mediates disease in a mouse model of primary Sjogren's disease.
Title: TLR7 activation of age-associated B cells mediates disease in a mouse model of primary Sjögren's disease.
TLR7 enhancing follicular helper T (Tfh) cells response in C57BL/6 mice infected with Plasmodium yoelii NSM TLR7 mediated Tfh cells in P. yoelii infected mice.
Title: TLR7 enhancing follicular helper T (Tfh) cells response in C57BL/6 mice infected with Plasmodium yoelii NSM TLR7 mediated Tfh cells in P. yoelii infected mice.
Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis.
Title: Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis.
TLR7 promotes chronic airway disease in RSV-infected mice.
Title: TLR7 promotes chronic airway disease in RSV-infected mice.
TLR7 promotes skin inflammation via activating NFkappaB-mTORC1 axis in rosacea.
Title: TLR7 promotes skin inflammation via activating NFκB-mTORC1 axis in rosacea.
CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis.
Title: CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis.
EGF-Receptor-Dependent TLR7 Signaling in Macrophages Promotes Glomerular Injury in Crescentic Glomerulonephritis.
Title: EGF-Receptor-Dependent TLR7 Signaling in Macrophages Promotes Glomerular Injury in Crescentic Glomerulonephritis.
TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity.
Title: TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity.

Submit: New GeneRIF Correction See all GeneRIFs (308)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Chemically induced (ENU) (2)
Endonuclease-mediated (9) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

DXMit223 (e-PCR), detects polymorphism
- UniSTS:132113

px-71b8 (e-PCR)
- UniSTS:258160

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables siRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables single-stranded RNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in I-kappaB phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within macrophage cytokine production	IC Inferred by Curator more info	PubMed
acts_upstream_of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cGMP	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 7 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 7 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in early phagosome	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: toll-like receptor 7

Names: Toll like receptor 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290755.1 → NP_001277684.1 toll-like receptor 7 isoform a precursor

See identical proteins and their annotated locations for NP_001277684.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1, 2, 3, and 4 encode the same isoform (a).

Source sequence(s)

AJ812654, AK036549, AL731735, BY543663

Consensus CDS

CCDS72469.1

UniProtKB/Swiss-Prot

P58681, Q923I1

UniProtKB/TrEMBL

Q548J0, U5LI18

Related

ENSMUSP00000107787.2, ENSMUST00000112161.8

Conserved Domains (5) summary

PRK15370
Location:32 → 243

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:754 → 838

PCC; polycystin cation channel protein

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:174 → 786

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]
NM_001290756.1 → NP_001277685.1 toll-like receptor 7 isoform a precursor

See identical proteins and their annotated locations for NP_001277685.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' region, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).

Source sequence(s)

AJ812654, AK036549, AL731735, BY543663

Consensus CDS

CCDS72469.1

UniProtKB/Swiss-Prot

P58681, Q923I1

UniProtKB/TrEMBL

Q548J0, U5LI18

Conserved Domains (5) summary

PRK15370
Location:32 → 243

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:754 → 838

PCC; polycystin cation channel protein

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:174 → 786

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]
NM_001290757.1 → NP_001277686.1 toll-like receptor 7 isoform a precursor

See identical proteins and their annotated locations for NP_001277686.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate exons and uses an alternate splice site in the 5' region, and initiates translation from an alternate upstream start codon, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).

Source sequence(s)

AK036549, AL731735, BY543663

Consensus CDS

CCDS30531.1

UniProtKB/Swiss-Prot

P58681, Q923I1

UniProtKB/TrEMBL

Q548J0, U5LI18

Related

ENSMUSP00000107789.2, ENSMUST00000112164.2

Conserved Domains (5) summary

PRK15370
Location:32 → 243

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:754 → 838

PCC; polycystin cation channel protein

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:174 → 786

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]
NM_001290758.1 → NP_001277687.1 toll-like receptor 7 isoform b precursor

See identical proteins and their annotated locations for NP_001277687.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate exon in the 5' region and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.

Source sequence(s)

AJ812652, AK036549, AL731735, BY204351, BY543663

UniProtKB/TrEMBL

U5LI18

Conserved Domains (5) summary

PRK15370
Location:35 → 246

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:757 → 841

PCC; polycystin cation channel protein

smart00255
Location:894 → 1039

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:177 → 789

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:500 → 522

LRR_RI; leucine-rich repeat [structural motif]
NM_133211.4 → NP_573474.1 toll-like receptor 7 isoform a precursor

See identical proteins and their annotated locations for NP_573474.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate exons in the 5' region and initiates translation from an alternate upstream start codon, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).

Source sequence(s)

AK036549, AL731735, BY543663

Consensus CDS

CCDS30531.1

UniProtKB/Swiss-Prot

P58681, Q923I1

UniProtKB/TrEMBL

Q548J0, U5LI18

Related

ENSMUSP00000061853.6, ENSMUST00000060719.12

Conserved Domains (5) summary

PRK15370
Location:32 → 243

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:754 → 838

PCC; polycystin cation channel protein

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:174 → 786

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

166086376..166113570 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528713.2 → XP_006528776.1 toll-like receptor 7 isoform X1

See identical proteins and their annotated locations for XP_006528776.1

UniProtKB/TrEMBL

U5LI18

Conserved Domains (5) summary

PRK15370
Location:35 → 246

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:757 → 841

PCC; polycystin cation channel protein

smart00255
Location:894 → 1039

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:177 → 789

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:500 → 522

LRR_RI; leucine-rich repeat [structural motif]