Format

Send to:

Choose Destination

Slc8b1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 [ Mus musculus (house mouse) ]

Gene ID: 170756, updated on 23-Jun-2021

Summary

Official Symbol
Slc8b1provided by MGI
Official Full Name
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1provided by MGI
Primary source
MGI:MGI:2180781
See related
Ensembl:ENSMUSG00000032754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NC; NCKX; NCLX; Slc2; NCKX6; Slc24a6; AF261233
Expression
Broad expression in colon adult (RPKM 34.9), spleen adult (RPKM 21.7) and 21 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Slc8b1 in Genome Data Viewer
Location:
5; 5 F
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120649233..120672089)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120511168..120534024)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (120961201..120984033)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene serine dehydratase-like Neighboring gene serine dehydratase Neighboring gene phospholipase B domain containing 2 Neighboring gene two pore channel 1 Neighboring gene IQ motif containing D Neighboring gene RBPJ interacting and tubulin associated 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in calcium export from the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium export from the mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium export from the mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cation transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitochondrial calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrial calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell membrane potential IC
Inferred by Curator
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lymphocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial crista ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial crista ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitochondrial sodium/calcium exchanger protein
Names
Na(+)/K(+)/Ca(2+)-exchange protein 6
sodium/calcium exchanger protein, mitochondrial
sodium/potassium/calcium exchanger 6, mitochondrial
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
solute carrier family 24 member 6
solute carrier family 8 member B1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177594.1NP_001171065.1  mitochondrial sodium/calcium exchanger protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001171065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate splice site, compared to variant 1. The resulting isoform (2) differs at an internal segment, compared to isoform 1.
    Source sequence(s)
    AC125183
    Consensus CDS
    CCDS51634.1
    UniProtKB/Swiss-Prot
    Q925Q3
    Related
    ENSMUSP00000107521.3, ENSMUST00000111890.9
    Conserved Domains (1) summary
    pfam01699
    Location:404557
    Na_Ca_ex; Sodium/calcium exchanger protein
  2. NM_001177595.1NP_001171066.1  mitochondrial sodium/calcium exchanger protein isoform 3 precursor

    See identical proteins and their annotated locations for NP_001171066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AC125183
    Consensus CDS
    CCDS51633.1
    UniProtKB/Swiss-Prot
    Q925Q3
    Related
    ENSMUSP00000075428.6, ENSMUST00000076051.12
    Conserved Domains (2) summary
    pfam01699
    Location:103246
    Na_Ca_ex; Sodium/calcium exchanger protein
    cl01507
    Location:82118
    EIID-AGA; PTS system mannose/fructose/sorbose family IID component
  3. NM_133221.2NP_573484.2  mitochondrial sodium/calcium exchanger protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_573484.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF261233, AK028537, BP766040
    Consensus CDS
    CCDS39238.1
    UniProtKB/Swiss-Prot
    Q925Q3
    Related
    ENSMUSP00000064714.8, ENSMUST00000068326.14
    Conserved Domains (1) summary
    pfam01699
    Location:421574
    Na_Ca_ex; Sodium/calcium exchanger protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    120649233..120672089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530174.1XP_006530237.1  mitochondrial sodium/calcium exchanger protein isoform X1

    Conserved Domains (1) summary
    PLN03151
    Location:63578
    PLN03151; cation/calcium exchanger; Provisional
  2. XM_006530175.2XP_006530238.1  mitochondrial sodium/calcium exchanger protein isoform X2

    Conserved Domains (1) summary
    PLN03151
    Location:63430
    PLN03151; cation/calcium exchanger; Provisional

RNA

  1. XR_003955590.1 RNA Sequence

Support Center