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Rac3 Rac family small GTPase 3 [ Mus musculus (house mouse) ]

Gene ID: 170758, updated on 25-Jan-2022

Summary

Official Symbol
Rac3provided by MGI
Official Full Name
Rac family small GTPase 3provided by MGI
Primary source
MGI:MGI:2180784
See related
Ensembl:ENSMUSG00000018012 AllianceGenome:MGI:2180784
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rac1B
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activity; and calcium-dependent protein binding activity. Acts upstream of or within several processes, including GABAergic synaptic transmission; neuron development; and regulation of neuron maturation. Predicted to be located in several cellular components, including growth cone; neuronal cell body; and perinuclear region of cytoplasm. Predicted to be part of filamentous actin. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and neuron projection. Is expressed in brain and genitourinary system. Orthologous to human RAC3 (Rac family small GTPase 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in CNS E18 (RPKM 162.4), whole brain E14.5 (RPKM 74.7) and 10 other tissues See more
Orthologs
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Genomic context

See Rac3 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120612294..120614795)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120721468..120723969)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120582782..120585283)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene centromere protein X Neighboring gene leucine rich repeat containing 45 Neighboring gene dicarbonyl L-xylulose reductase Neighboring gene carbonyl reductase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell projection assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebral cortex GABAergic interneuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cortical cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuromuscular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of neuron maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
 
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related C3 botulinum toxin substrate 3
Names
RAS-related C3 botulinum substrate 3
p21-Rac3
NP_573486.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133223.4NP_573486.1  ras-related C3 botulinum toxin substrate 3

    See identical proteins and their annotated locations for NP_573486.1

    Status: PROVISIONAL

    Source sequence(s)
    AL663030
    Consensus CDS
    CCDS25754.1
    UniProtKB/Swiss-Prot
    P60764
    UniProtKB/TrEMBL
    Q14A12
    Related
    ENSMUSP00000018156.6, ENSMUST00000018156.12
    Conserved Domains (1) summary
    cd01871
    Location:3176
    Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120612294..120614795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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