U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta [ Mus musculus (house mouse) ]

Gene ID: 170826, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ppargc1bprovided by MGI
Official Full Name
peroxisome proliferative activated receptor, gamma, coactivator 1 betaprovided by MGI
Primary source
MGI:MGI:2444934
See related
Ensembl:ENSMUSG00000033871 AllianceGenome:MGI:2444934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Perc; PGC-1beta; 4631412G21Rik; PPARGC-1-beta; PGC-1beta/ERRL1
Summary
Predicted to enable AF-2 domain binding activity; estrogen receptor binding activity; and nuclear receptor coactivator activity. Involved in several processes, including bone trabecula formation; positive regulation of phosphate metabolic process; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mediator complex. Predicted to be active in nucleus. Is expressed in brown fat; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 4.4), colon adult (RPKM 3.6) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ppargc1b in Genome Data Viewer
Location:
18 E1; 18 34.41 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61424516..61533846, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61291445..61400756, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7591 Neighboring gene solute carrier family 26 (sulfate transporter), member 2 Neighboring gene STARR-seq mESC enhancer starr_44740 Neighboring gene predicted gene, 52353 Neighboring gene phosphodiesterase 6A, cGMP-specific, rod, alpha Neighboring gene STARR-seq mESC enhancer starr_44743 Neighboring gene ribosomal protein S2, pseudogene 10 Neighboring gene STARR-seq mESC enhancer starr_44744 Neighboring gene predicted gene, 46627 Neighboring gene STARR-positive B cell enhancer ABC_E10995 Neighboring gene microRNA 378a Neighboring gene predicted gene, 52354 Neighboring gene predicted gene 8755 Neighboring gene predicted gene, 25834

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds. Schmid S, et al. Mol Metab, 2022 Dec. PMID 36400401, Free PMC Article
  2. Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat. Funda J, et al. Dis Model Mech, 2022 Apr 1. PMID 35466996, Free PMC Article
  3. PGC-1β Induces Susceptibility To Acetaminophen-Driven Acute Liver Failure. Piccinin E, et al. Sci Rep, 2019 Nov 14. PMID 31727907, Free PMC Article
  4. Ageing in Pgc-1β(-/-) mice modelling mitochondrial dysfunction induces differential expression of a range of genes regulating ventricular electrophysiology. Edling CE, et al. Biosci Rep, 2019 Apr 30. PMID 30914453, Free PMC Article
  5. Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β(-/-)) murine hearts. Ahmad S, et al. Mech Ageing Dev, 2018 Jul. PMID 29763629, Free PMC Article

See all (135) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dancr-BRG1 regulates Nfatc1 transcription and Pgc1beta-dependent metabolic shifts in osteoclastogenesis.
    Title: Dancr-BRG1 regulates Nfatc1 transcription and Pgc1β-dependent metabolic shifts in osteoclastogenesis.
  2. PGC-1beta modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds.
    Title: PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds.
  3. Adipose tissue-specific ablation of PGC-1beta impairs thermogenesis in brown fat.
    Title: Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat.
  4. FOXO1 suppresses PGC-1beta gene expression in skeletal muscles.
    Title: FOXO1 suppresses PGC-1β gene expression in skeletal muscles.
  5. Hepcidin-induced reduction in iron content and PGC-1beta expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis.
    Title: Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis.
  6. PGC-1beta-expressing POMC neurons mediate the effect of leptin on thermoregulation in the mouse.
    Title: PGC-1β-expressing POMC neurons mediate the effect of leptin on thermoregulation in the mouse.
  7. miR-378 and its host gene Ppargc1beta exhibit independent expression in mouse skeletal muscle.
    Title: miR-378 and its host gene Ppargc1β exhibit independent expression in mouse skeletal muscle.
  8. PGC-1beta Induces Susceptibility To Acetaminophen-Driven Acute Liver Failure.
    Title: PGC-1β Induces Susceptibility To Acetaminophen-Driven Acute Liver Failure.
  9. A novel long noncoding RNA PGC1beta-OT1 regulates adipocyte and osteoblast differentiation through antagonizing miR-148a-3p.
    Title: A novel long noncoding RNA PGC1β-OT1 regulates adipocyte and osteoblast differentiation through antagonizing miR-148a-3p.
  10. LXRalpha selectively activates transcription of miR-378 and inhibits expression of Ppargc1beta, which synergistically impairs fatty acid oxidation (FAO). In addition to lipogenesis, impaired FAO by miR-378 contributes to LXRalpha-induced hepatosteatosis
    Title: LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA-378 Transcription and Inhibition of Ppargc1β Expression.
Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (11)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AF-2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bone trabecula formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of alkaline phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
peroxisome proliferator-activated receptor gamma coactivator 1-beta
Names
ERR ligand 1
PPAR gamma coactivator-1beta protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364996.1 → NP_001351925.1  peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116595, AC121903
    Consensus CDS
    CCDS89250.1
    UniProtKB/TrEMBL
    B2RWT8
    Related
    ENSMUSP00000069431.6, ENSMUST00000063307.6
    Conserved Domains (2) summary
    cd12356
    Location:907 → 986
    RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins
    cl28087
    Location:178 → 443
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  2. NM_133249.3 → NP_573512.1  peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1

    See identical proteins and their annotated locations for NP_573512.1

    Status: VALIDATED

    Source sequence(s)
    AC116595, AC121903
    Consensus CDS
    CCDS29284.1
    UniProtKB/Swiss-Prot
    Q8C1C0, Q8VHJ7
    UniProtKB/TrEMBL
    B2RWT8
    Related
    ENSMUSP00000074771.7, ENSMUST00000075299.13
    Conserved Domains (1) summary
    cd12356
    Location:891 → 970
    RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61424516..61533846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525698.4 → XP_006525761.1  peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X1

    UniProtKB/TrEMBL
    B2RWT8
    Conserved Domains (2) summary
    PRK10263
    Location:194 → 459
    PRK10263; DNA translocase FtsK; Provisional
    cd12356
    Location:923 → 1002
    RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHJ7.1 GenPept UniProtKB/Swiss-Prot:Q8VHJ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous