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Inpp5j inositol polyphosphate 5-phosphatase J [ Mus musculus (house mouse) ]

Gene ID: 170835, updated on 11-Apr-2024

Summary

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Official Symbol
Inpp5jprovided by MGI
Official Full Name
inositol polyphosphate 5-phosphatase Jprovided by MGI
Primary source
MGI:MGI:2158663
See related
Ensembl:ENSMUSG00000034570 AllianceGenome:MGI:2158663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pipp; Pib5pa
Summary
Enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. Acts upstream of or within negative regulation of neuron projection development and negative regulation of peptidyl-serine phosphorylation. Located in dendritic shaft; growth cone; and plasma membrane. Is expressed in alimentary system; ear; nervous system; respiratory system; and skeleton. Orthologous to human INPP5J (inositol polyphosphate-5-phosphatase J). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 37.0), frontal lobe adult (RPKM 26.8) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Inpp5j in Genome Data Viewer
Location:
11 A1; 11 2.45 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3444272..3455521, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3494272..3505501, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 185 Neighboring gene RIKEN cDNA 8430429K09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3352424-3352533 Neighboring gene predicted gene, 53661 Neighboring gene 39S ribosomal protein L30, mitochondrial pseudogene Neighboring gene phospholipase A2, group III Neighboring gene selenoprotein M Neighboring gene smoothelin Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3435535-3435644 Neighboring gene STARR-positive B cell enhancer mm9_chr11:3439140-3439441 Neighboring gene predicted gene 11946

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a great increase of proline-rich inositol polyphosphate 5-phosphatase (PIPP) level in oocytes. Yu H, et al. In Vitro Cell Dev Biol Anim, 2021 Mar. PMID 33537929
  2. The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation. Ooms LM, et al. Mol Biol Cell, 2006 Feb. PMID 16280363, Free PMC Article
  3. The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis. Ooms LM, et al. Cancer Cell, 2015 Aug 10. PMID 26267533
  4. Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. Gurung R, et al. J Biol Chem, 2003 Mar 28. PMID 12536145
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a great increase of proline-rich inositol polyphosphate 5-phosphatase (PIPP) level in oocytes.
    Title: Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a great increase of proline-rich inositol polyphosphate 5-phosphatase (PIPP) level in oocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-polyphosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
Names
phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A
phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase
phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase
proline-rich inositol polyphosphate 5-phosphatase
NP_766027.2
XP_030101477.1
XP_030101478.1
XP_030101479.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172439.3 → NP_766027.2  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

    See identical proteins and their annotated locations for NP_766027.2

    Status: VALIDATED

    Source sequence(s)
    BC131634, BY235850, BY629401
    Consensus CDS
    CCDS24364.1
    UniProtKB/Swiss-Prot
    P59644, Q3TDM9
    UniProtKB/TrEMBL
    Q3TBW1
    Related
    ENSMUSP00000046625.6, ENSMUST00000044507.12
    Conserved Domains (3) summary
    cd09094
    Location:420 → 727
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
    PHA03247
    Location:50 → 337
    PHA03247; large tegument protein UL36; Provisional
    pfam17751
    Location:738 → 836
    SKICH; SKICH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3444272..3455521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245617.2 → XP_030101477.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1

    UniProtKB/Swiss-Prot
    P59644, Q3TDM9
    UniProtKB/TrEMBL
    Q3TBW1
    Conserved Domains (3) summary
    cd09094
    Location:420 → 727
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
    PHA03247
    Location:50 → 337
    PHA03247; large tegument protein UL36; Provisional
    pfam17751
    Location:738 → 836
    SKICH; SKICH domain

  2. XM_030245618.1 → XP_030101478.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1

    UniProtKB/Swiss-Prot
    P59644, Q3TDM9
    UniProtKB/TrEMBL
    Q3TBW1
    Conserved Domains (3) summary
    cd09094
    Location:420 → 727
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
    PHA03247
    Location:50 → 337
    PHA03247; large tegument protein UL36; Provisional
    pfam17751
    Location:738 → 836
    SKICH; SKICH domain

  3. XM_030245619.2 → XP_030101479.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X2

    UniProtKB/TrEMBL
    A0A075B6D7
    Related
    ENSMUSP00000139302.2, ENSMUST00000154756.2
    Conserved Domains (3) summary
    cd09094
    Location:420 → 727
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
    PHA03247
    Location:50 → 337
    PHA03247; large tegument protein UL36; Provisional
    pfam17751
    Location:738 → 835
    SKICH; SKICH domain

RNA

  1. XR_003949330.2 RNA Sequence

  2. XR_003949331.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59644.2 GenPept UniProtKB/Swiss-Prot:P59644

Gene LinkOut

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