Ly86 lymphocyte antigen 86 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ly86provided by MGI
Official Full Name: lymphocyte antigen 86provided by MGI
Primary source: MGI:MGI:1321404
See related: Ensembl:ENSMUSG00000021423 AllianceGenome:MGI:1321404
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MD1; MD-1; ly86_tv2
Summary: Acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in extracellular region. Is expressed in cerebral cortex; genitourinary system; and lower leg bone. Orthologous to human LY86 (lymphocyte antigen 86). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 21.0), mammary gland adult (RPKM 11.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.3; 13 14.7 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (37529276..37603012)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (37345345..37419036)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of MD1 Promotes Inflammatory and Apoptotic Atrial Remodelling in Diabetic Cardiomyopathy by Activating the TLR4/NF-kappaB Signalling Pathway.
Title: Loss of MD1 Promotes Inflammatory and Apoptotic Atrial Remodelling in Diabetic Cardiomyopathy by Activating the TLR4/NF-κB Signalling Pathway.
MD1 Depletion Predisposes to Ventricular Arrhythmias in the Setting of Myocardial Infarction.
Title: MD1 Depletion Predisposes to Ventricular Arrhythmias in the Setting of Myocardial Infarction.
MD1 deletion exaggerates cardiomyocyte autophagy induced by heart failure with preserved ejection fraction through ROS/MAPK signalling pathway.
Title: MD1 deletion exaggerates cardiomyocyte autophagy induced by heart failure with preserved ejection fraction through ROS/MAPK signalling pathway.
Knockout of MD1 contributes to sympathetic hyperactivity and exacerbates ventricular arrhythmias following heart failure with preserved ejection fraction via NLRP3 inflammasome activation.
Title: Knockout of MD1 contributes to sympathetic hyperactivity and exacerbates ventricular arrhythmias following heart failure with preserved ejection fraction via NLRP3 inflammasome activation.
The effect of MD1 on potassium and L-type calcium current of cardiomyocytes from high-fat diet mice.
Title: The effect of MD1 on potassium and L-type calcium current of cardiomyocytes from high-fat diet mice.
Inhibition of myeloid differentiation 1 specifically in colon with antisense oligonucleotide exacerbates dextran sodium sulfate-induced colitis.
Title: Inhibition of myeloid differentiation 1 specifically in colon with antisense oligonucleotide exacerbates dextran sodium sulfate-induced colitis.
MD1 deficiency played an important role in accelerating the development of in fl ammatory atrial fibrosis and increasing vulnerability to AF in mice with HFD-fed induced obesity, providing an essential target for improving HFD-induced atrial remodelling.
Title: MD1 Deficiency Promotes Inflammatory Atrial Remodelling Induced by High-Fat Diets.
These findings indicate that endogenous MD1 protects against myocardial I/R injury and I/R-induced arrhythmia. Thus, MD1 upregulation may be a new target for the treatment of myocardial I/R injury and arrhythmia and should be further researched in future experiments.
Title: Loss of MD1 exacerbates myocardial ischemia/reperfusion injury and susceptibility to ventricular arrhythmia.
The present study shows that a noncanonical Toll-like receptor complex, CD180/MD-1, is specifically expressed on Multiple myeloma cells and senses bacterial lipopolysaccharide to transduce proliferative signals, leading to the regrowth of dormant Multiple myeloma clones.
Title: Myeloma Cells Are Activated in Bone Marrow Microenvironment by the CD180/MD-1 Complex, Which Senses Lipopolysaccharide.
Study discovered that pressure overload-induced left ventriclar remodeling was aggravated in MD1-knockout mice, which led to overt heart failure and increased electrophysiological instability.
Title: Loss of MD1 exacerbates pressure overload-induced left ventricular structural and electrical remodelling.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of lipopolysaccharide-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lymphocyte antigen 86

Names: ly-86; protein MD-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001426188.1 → NP_001413117.1 lymphocyte antigen 86 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC154595, CT030182
NM_001426189.1 → NP_001413118.1 lymphocyte antigen 86 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC154595, CT030182
NM_001426190.1 → NP_001413119.1 lymphocyte antigen 86 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC154595, CT030182
NM_001426191.1 → NP_001413120.1 lymphocyte antigen 86 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC154595, CT030182

UniProtKB/TrEMBL

A0A0U5J712
NM_010745.3 → NP_034875.1 lymphocyte antigen 86 isoform 1 precursor

See identical proteins and their annotated locations for NP_034875.1

Status: VALIDATED

Source sequence(s)

AC154595, CT030182

Consensus CDS

CCDS26457.1

UniProtKB/Swiss-Prot

O88188, Q4VAF1, Q5D046

Related

ENSMUSP00000021860.6, ENSMUST00000021860.7

Conserved Domains (1) summary

cl00274
Location:30 → 159

ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

37529276..37603012

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157880.1 → XP_036013773.1 lymphocyte antigen 86 isoform X1

Conserved Domains (1) summary

cl00274
Location:30 → 118

ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...