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Ndel1 nudE neurodevelopment protein 1-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170845, updated on 30-Sep-2021

Summary

Official Symbol
Ndel1provided by RGD
Official Full Name
nudE neurodevelopment protein 1-like 1provided by RGD
Primary source
RGD:621235
See related
EnsemblRapid:ENSRNOG00000004139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
EOPA; NUDE2; Nudel
Summary
a LIS1-interacting protein [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 224.5), Spleen (RPKM 156.1) and 9 other tissues See more
Orthologs
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Genomic context

See Ndel1 in Genome Data Viewer
Location:
10q24
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53505628..53582025, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55398919..55456654, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene similar to microfibrillar-associated protein 1 Neighboring gene myosin heavy chain 10 Neighboring gene 60S ribosomal protein L30-like Neighboring gene peroxiredoxin-6-like Neighboring gene ring finger protein 222

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables oligopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within central nervous system neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in centrosome localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within centrosome localization ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebral cortex radially oriented cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of chromosome localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within inner cell mass cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosome localization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic centrosome separation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mitotic centrosome separation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neurofilament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nuclear membrane disassembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ruffle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retrograde axonal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vesicle transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in axon hillock ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in central region of growth cone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of kinesin complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
part_of microtubule associated complex ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
located_in neurofilament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear distribution protein nudE-like 1
Names
LIS1-interacting protein NUDEL
LIS1-interacting protein NUDEL; endooligopeptidase A
endooligopeptidase A
nuclear distribution gene E-like homolog 1
nudE nuclear distribution gene E homolog like 1
protein Nudel

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133320.2NP_579854.1  nuclear distribution protein nudE-like 1

    See identical proteins and their annotated locations for NP_579854.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000220
    UniProtKB/Swiss-Prot
    Q78PB6
    Related
    ENSRNOP00000090924.1, ENSRNOT00000098446.1
    Conserved Domains (2) summary
    TIGR02168
    Location:24195
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam04880
    Location:135309
    NUDE_C; NUDE protein, C-terminal conserved region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    53505628..53582025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596976.2XP_017452465.1  nuclear distribution protein nudE-like 1 isoform X3

    Related
    ENSRNOP00000097143.1, ENSRNOT00000111866.1
  2. XM_039085116.1XP_038941044.1  nuclear distribution protein nudE-like 1 isoform X1

    Conserved Domains (2) summary
    TIGR02168
    Location:24195
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam04880
    Location:135309
    NUDE_C; NUDE protein, C-terminal conserved region
  3. XM_006246578.4XP_006246640.1  nuclear distribution protein nudE-like 1 isoform X2

    See identical proteins and their annotated locations for XP_006246640.1

    UniProtKB/Swiss-Prot
    Q78PB6
    Related
    ENSRNOP00000005574.6, ENSRNOT00000005574.8
    Conserved Domains (2) summary
    TIGR02168
    Location:24195
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam04880
    Location:135309
    NUDE_C; NUDE protein, C-terminal conserved region
  4. XM_039085117.1XP_038941045.1  nuclear distribution protein nudE-like 1 isoform X1

    Conserved Domains (2) summary
    TIGR02168
    Location:24195
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam04880
    Location:135309
    NUDE_C; NUDE protein, C-terminal conserved region
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