Ndel1 nudE neurodevelopment protein 1-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndel1provided by RGD
Official Full Name: nudE neurodevelopment protein 1-like 1provided by RGD
Primary source: RGD:621235
See related: Ensembl:ENSRNOG00000004139 AllianceGenome:RGD:621235
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EOPA; NUDE2; Nudel
Summary: Enables oligopeptidase activity. Involved in neuron projection development; positive regulation of axon extension; and positive regulation of axon regeneration. Acts upstream of or within nuclear membrane disassembly. Located in several cellular components, including central region of growth cone; centrosome; and nuclear envelope. Part of kinesin complex. Orthologous to human NDEL1 (nudE neurodevelopment protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 224.5), Spleen (RPKM 156.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54001435..54080909, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (53505628..53582025, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (55398919..55456654, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

knocking down both Ndel1 and NudCL almost blocked retrograde mitochondrial axonal transport.
Title: Distinct functions of nuclear distribution proteins LIS1, Ndel1 and NudCL in regulating axonal mitochondrial transport.
The results did not detect a significant association. It indicated that common genetic variations in NDEL1 genes might not play a role in the genetic predisposition to autism.
Title: No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population.
genetic variants of disrupted in schizophrenia 1 (DISC1), proximal to the NDEL1 binding site, affect the interaction between DISC1 and NDEL1
Title: DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.
Together, these results indicate that DISC1 regulates the localization of NUDEL/LIS1/14-3-3epsilon complex into the axons as a cargo receptor for axon elongation.
Title: DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133557 (e-PCR)
- UniSTS:216840

Ndel1 (e-PCR), detects polymorphism
- UniSTS:499127

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	IEA Inferred from Electronic Annotation more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables oligopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system neuron axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in centrosome localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within centrosome localization	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex radially oriented cell migration	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex radially oriented cell migration	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in establishment of chromosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner cell mass cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner cell mass cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	IEA Inferred from Electronic Annotation more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic centrosome separation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic centrosome separation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic centrosome separation	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neurofilament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurofilament cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron projection extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear membrane disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ruffle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ruffle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in radial glia-guided pyramidal neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within radial glia-guided pyramidal neuron migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in retrograde axonal transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retrograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle transport along microtubule	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axon hillock	IEA Inferred from Electronic Annotation more info
located_in axon hillock	ISO Inferred from Sequence Orthology more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in central region of growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in neurofilament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in neurofilament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear distribution protein nudE-like 1

Names: LIS1-interacting protein NUDEL; LIS1-interacting protein NUDEL; endooligopeptidase A; endooligopeptidase A; nuclear distribution gene E-like homolog 1; nudE nuclear distribution gene E homolog like 1; protein Nudel

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133320.2 → NP_579854.1 nuclear distribution protein nudE-like 1

See identical proteins and their annotated locations for NP_579854.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q6IRI4, Q78PB6

UniProtKB/TrEMBL

A0A8I6AEF7, A6HFL2

Related

ENSRNOP00000090924.1, ENSRNOT00000098446.1

Conserved Domains (2) summary

TIGR02168
Location:24 → 195

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam04880
Location:135 → 309

NUDE_C; NUDE protein, C-terminal conserved region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

54001435..54080909 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596976.3 → XP_017452465.1 nuclear distribution protein nudE-like 1 isoform X4

UniProtKB/TrEMBL

A0A8I6A433, A0A8I6AR01

Related

ENSRNOP00000097143.1
XM_039085116.2 → XP_038941044.1 nuclear distribution protein nudE-like 1 isoform X2

UniProtKB/Swiss-Prot

Q6IRI4, Q78PB6

UniProtKB/TrEMBL

A0A8I6AEF7, A6HFL2

Conserved Domains (2) summary

TIGR02168
Location:24 → 195

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam04880
Location:135 → 309

NUDE_C; NUDE protein, C-terminal conserved region
XM_063268360.1 → XP_063124430.1 nuclear distribution protein nudE-like 1 isoform X3
XM_006246578.5 → XP_006246640.1 nuclear distribution protein nudE-like 1 isoform X3

See identical proteins and their annotated locations for XP_006246640.1

UniProtKB/TrEMBL

A0A8I6A433

Related

ENSRNOP00000005574.6

Conserved Domains (2) summary

TIGR02168
Location:24 → 195

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam04880
Location:135 → 309

NUDE_C; NUDE protein, C-terminal conserved region
XM_063268359.1 → XP_063124429.1 nuclear distribution protein nudE-like 1 isoform X1
XM_063268361.1 → XP_063124431.1 nuclear distribution protein nudE-like 1 isoform X3
XM_039085117.2 → XP_038941045.1 nuclear distribution protein nudE-like 1 isoform X2

UniProtKB/Swiss-Prot

Q6IRI4, Q78PB6

UniProtKB/TrEMBL

A0A8I6AEF7, A6HFL2

Conserved Domains (2) summary

TIGR02168
Location:24 → 195

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam04880
Location:135 → 309

NUDE_C; NUDE protein, C-terminal conserved region