Ncr1 natural cytotoxicity triggering receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncr1provided by MGI
Official Full Name: natural cytotoxicity triggering receptor 1provided by MGI
Primary source: MGI:MGI:1336212
See related: Ensembl:ENSMUSG00000062524 AllianceGenome:MGI:1336212
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly94; Cd335; NKp46
Summary: Acts upstream of or within defense response to virus and detection of virus. Located in cell surface. Orthologous to human NCR1 (natural cytotoxicity triggering receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 2.2), lung adult (RPKM 0.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.5 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (4340714..4348183)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (4337715..4345184)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NK cell-activating receptor NKp46 does not participate in the development of obesity-induced inflammation and insulin resistance.
Title: NK cell-activating receptor NKp46 does not participate in the development of obesity-induced inflammation and insulin resistance.
Tumor-associated NK cells facilitate tumor growth via NKp46 in immunocompetent murine hepatocellular carcinoma.
Title: Tumor-associated NK cells facilitate tumor growth via NKp46 in immunocompetent murine hepatocellular carcinoma.
The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells.
Title: The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells.
NKp46(+) natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection.
Title: NKp46(+) natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection.
The transcription factor HIF-1alpha mediates plasticity of NKp46+ innate lymphoid cells in the gut.
Title: The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.
Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity.
Title: Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity.
Studies uncover a link between NKp46 and TRAIL expression in ILCs with potential implications in pathologies involving NKp46-expressing cells.
Title: The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1s.
Most of the natural killer cell p46-related protein (NKp46) and NK cell Lectin-like receptor subfamily A (Ly49A) molecules were restricted to microdomains; however, individual NKp46 molecules resided in these domains for shorter periods and diffused faster on the surface of educated, compared to hyporesponsive, NK cells.
Title: Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A.
we show that NKG2D sets activation threshold for NCR1 early in NK cell development, which determines the sensitivity of NK cells to cellular targets expressing NCR1 ligands.
Title: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development.
A role of NKp46 in ILC1s that calibrates their antitumor response.
Title: NKp46 Calibrates Tumoricidal Potential of Type 1 Innate Lymphocytes by Regulating TRAIL Expression.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (5) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (17) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484921

Ncr1 (e-PCR), detects polymorphism
- UniSTS:256446

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: natural cytotoxicity triggering receptor 1

Names: MAR1 (mouse activating receptor 1); NK-p46; activating receptor 1; lymphocyte antigen 94; mAR-1; mNKp46; natural killer cell p46-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.