Marf1 meiosis regulator and mRNA stability factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Marf1provided by RGD
Full Name: meiosis regulator and mRNA stability factor 1provided by RGD
Primary source: RGD:619770
See related: Ensembl:ENSRNOG00000056248 AllianceGenome:RGD:619770
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lkap
Summary: Predicted to enable CCR4-NOT complex binding activity and mRNA binding activity involved in posttranscriptional gene silencing. Predicted to be involved in female meiotic nuclear division; oogenesis; and posttranscriptional gene silencing. Predicted to act upstream of or within double-strand break repair. Predicted to be located in Golgi apparatus and peroxisome. Predicted to be active in cytoplasm. Orthologous to human MARF1 (meiosis regulator and mRNA stability factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 255.8), Spleen (RPKM 208.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q11

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (1395271..1439974)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (888053..932760)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (908806..953481)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

C87306 (e-PCR)
- UniSTS:209168

RH129984 (e-PCR)
- UniSTS:213272

4921513D23Rik (e-PCR), detects polymorphism
- UniSTS:479058

D10Mco48 (e-PCR)
- UniSTS:240227

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CCR4-NOT complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA nuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in female meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in female meiotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	ISO Inferred from Sequence Orthology more info
involved_in oogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: meiosis regulator and mRNA stability factor 1

Names: limkain-b1; meiosis arrest female 1; meiosis arrest female protein 1; meiosis arrest female protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133421.3 → NP_596912.2 meiosis regulator and mRNA stability factor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

F1LNE9, Q8VIG2

Related

ENSRNOP00000073018.1, ENSRNOT00000091520.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

1395271..1439974

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245854.5 → XP_006245916.1 meiosis regulator and mRNA stability factor 1 isoform X2

UniProtKB/TrEMBL

A6KU39

Conserved Domains (10) summary

cd09978
Location:987 → 1057

LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)

cd09979
Location:1083 → 1154

LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)

cd09980
Location:1159 → 1230

LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)

cd09981
Location:1243 → 1313

LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)

cd09983
Location:1395 → 1467

LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)

cd09984
Location:1470 → 1545

LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)

cd10910
Location:350 → 492

limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins

cd12255
Location:507 → 579

RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins

cd12256
Location:770 → 858

RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

cl14879
Location:1319 → 1389

LabA_like_C; C-terminal domain of LabA_like proteins
XM_006245856.5 → XP_006245918.1 meiosis regulator and mRNA stability factor 1 isoform X4

UniProtKB/TrEMBL

A6KU39

Conserved Domains (10) summary

cd09978
Location:822 → 892

LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)

cd09979
Location:918 → 989

LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)

cd09980
Location:994 → 1065

LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)

cd09981
Location:1078 → 1148

LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)

cd09983
Location:1230 → 1302

LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)

cd09984
Location:1305 → 1380

LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)

cd10910
Location:171 → 313

limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins

cd12255
Location:328 → 400

RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins

cd12256
Location:605 → 693

RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

cl14879
Location:1154 → 1224

LabA_like_C; C-terminal domain of LabA_like proteins
XM_063268363.1 → XP_063124433.1 meiosis regulator and mRNA stability factor 1 isoform X5
XM_063268364.1 → XP_063124434.1 meiosis regulator and mRNA stability factor 1 isoform X6
XM_063268362.1 → XP_063124432.1 meiosis regulator and mRNA stability factor 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K0S5
XM_003750779.6 → XP_003750827.1 meiosis regulator and mRNA stability factor 1 isoform X1

See identical proteins and their annotated locations for XP_003750827.1

UniProtKB/Swiss-Prot

F1LNE9, Q8VIG2

UniProtKB/TrEMBL

A6KU39

Conserved Domains (10) summary

cd09978
Location:1001 → 1071

LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)

cd09979
Location:1097 → 1168

LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)

cd09980
Location:1173 → 1244

LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)

cd09981
Location:1257 → 1327

LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)

cd09983
Location:1409 → 1481

LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)

cd09984
Location:1484 → 1559

LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)

cd10910
Location:350 → 492

limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins

cd12255
Location:507 → 579

RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins

cd12256
Location:784 → 872

RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

cl14879
Location:1333 → 1403

LabA_like_C; C-terminal domain of LabA_like proteins
XM_006245855.5 → XP_006245917.1 meiosis regulator and mRNA stability factor 1 isoform X3

See identical proteins and their annotated locations for XP_006245917.1

UniProtKB/TrEMBL

A0A0G2K0S5, A6KU39

Related

ENSRNOP00000071564.2

Conserved Domains (10) summary

cd09978
Location:955 → 1025

LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)

cd09979
Location:1051 → 1122

LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)

cd09980
Location:1127 → 1198

LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)

cd09981
Location:1211 → 1281

LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)

cd09983
Location:1363 → 1435

LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)

cd09984
Location:1438 → 1513

LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)

cd10910
Location:304 → 446

limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins

cd12255
Location:461 → 533

RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins

cd12256
Location:738 → 826

RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins

cl14879
Location:1287 → 1357

LabA_like_C; C-terminal domain of LabA_like proteins