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Fbxo32 F-box protein 32 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171043, updated on 30-Sep-2021

Summary

Official Symbol
Fbxo32provided by RGD
Official Full Name
F-box protein 32provided by RGD
Primary source
RGD:620373
See related
EnsemblRapid:ENSRNOG00000006738
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MAFbx; Atrogin1
Summary
may act as an SCF-type E3 ubiquitin ligase; plays a role in skeletal atrophy [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 632.8), Heart (RPKM 532.2) and 7 other tissues See more
Orthologs
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Genomic context

See Fbxo32 in Genome Data Viewer
Location:
7q33
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (89731626..89764761, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (98065664..98098071, complement)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene small nucleolar RNA SNORA11 Neighboring gene N-terminal glutamine amidase 1 Neighboring gene uncharacterized LOC102549374 Neighboring gene uncharacterized LOC120093814 Neighboring gene kelch-like family member 38

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle atrophy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to denervation involved in regulation of muscle adaptation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to denervation involved in regulation of muscle adaptation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to denervation involved in regulation of muscle adaptation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to electrical stimulus involved in regulation of muscle adaptation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
F-box only protein 32
Names
atrogin-1
atrophy gene 1
muscle atrophy F-box protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133521.1NP_598205.1  F-box only protein 32

    See identical proteins and their annotated locations for NP_598205.1

    Status: PROVISIONAL

    Source sequence(s)
    AY059628
    UniProtKB/Swiss-Prot
    Q91Z62
    Related
    ENSRNOP00000010361.1, ENSRNOT00000010361.4
    Conserved Domains (1) summary
    pfam06881
    Location:252297
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    89731626..89764761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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