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Wfdc18 WAP four-disulfide core domain 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171059, updated on 30-Sep-2021

Summary

Official Symbol
Wfdc18provided by RGD
Official Full Name
WAP four-disulfide core domain 18provided by RGD
Primary source
RGD:619957
See related
EnsemblRapid:ENSRNOG00000037097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Expi; Kal1; WDNM1
Summary
may mediate the invasive and metastatic potential of mammary adenocarcinomas [RGD, Feb 2006]
Expression
Biased expression in Uterus (RPKM 19.6), Thymus (RPKM 9.1) and 2 other tissues See more
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Genomic context

See Wfdc18 in Genome Data Viewer
Location:
10q26
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68588818..68590972)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (71008709..71010863)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095161 Neighboring gene anosmin 1 Neighboring gene extracellular peptidase inhibitor-like Neighboring gene WAP four-disulfide core domain 21

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in biological_process ND
No biological Data available
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
WAP four-disulfide core domain protein 18
Names
Kallmann syndrome 1 sequence
anosmin-1
extracellular peptidase inhibitor
extracellular proteinase inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133537.2NP_598221.2  WAP four-disulfide core domain protein 18 precursor

    See identical proteins and their annotated locations for NP_598221.2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000220
    UniProtKB/TrEMBL
    F7FPN3
    Related
    ENSRNOP00000052774.3, ENSRNOT00000055923.4
    Conserved Domains (1) summary
    cd00199
    Location:1675
    WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    68588818..68590972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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