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Mpc1 mitochondrial pyruvate carrier 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171087, updated on 13-Apr-2024

Summary

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Official Symbol
Mpc1provided by RGD
Official Full Name
mitochondrial pyruvate carrier 1provided by RGD
Primary source
RGD:620902
See related
Ensembl:ENSRNOG00000012415 AllianceGenome:RGD:620902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Brp44l; SLC54A1
Summary
Predicted to enable pyruvate transmembrane transporter activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to act upstream of or within cellular response to leukemia inhibitory factor and mitochondrial acetyl-CoA biosynthetic process from pyruvate. Predicted to be located in mitochondrion. Predicted to be integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial pyruvate carrier deficiency. Orthologous to human MPC1 (mitochondrial pyruvate carrier 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 3557.4), Kidney (RPKM 2878.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (54985305..54996979, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (52437745..52449399, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (53026608..53038229, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene proline rich 18 Neighboring gene SFT2 domain containing 1 Neighboring gene uncharacterized LOC134482722 Neighboring gene C-C motif chemokine receptor 6 Neighboring gene centrosomal protein 43 Neighboring gene uncharacterized LOC134484997

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats. Liu Y, et al. Life Sci, 2023 Jul 15. PMID 37030616
  2. Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats. Mansour HM, et al. Neurochem Int, 2021 Nov. PMID 34481907
  3. Identification and functional expression of the mitochondrial pyruvate carrier. Herzig S, et al. Science, 2012 Jul 6. PMID 22628554
  4. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Bricker DK, et al. Science, 2012 Jul 6. PMID 22628558, Free PMC Article
  5. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats.
    Title: Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats.
  2. Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats.
    Title: Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables pyruvate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to pyruvate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables pyruvate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
  
involved_in acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial pyruvate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial pyruvate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitochondrial pyruvate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial pyruvate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial pyruvate transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial pyruvate carrier 1
Names
apoptosis-regulating basic protein
brain protein 44-like protein
solute carrier family 54 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133561.2 → NP_598245.1  mitochondrial pyruvate carrier 1

    See identical proteins and their annotated locations for NP_598245.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P63031, Q4V8N5
    Conserved Domains (1) summary
    pfam03650
    Location:24 → 105
    MPC; Uncharacterized protein family (UPF0041)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    54985305..54996979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274096.1 → XP_063130166.1  mitochondrial pyruvate carrier 1 isoform X3

    UniProtKB/Swiss-Prot
    P63031, Q4V8N5

  2. XM_063274062.1 → XP_063130132.1  mitochondrial pyruvate carrier 1 isoform X2

    UniProtKB/TrEMBL
    A6KK36

  3. XM_039086663.2 → XP_038942591.1  mitochondrial pyruvate carrier 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZR29, A0A8L2Q8K1, A6KK31
    Related
    ENSRNOP00000017282.6
    Conserved Domains (1) summary
    pfam03650
    Location:2 → 81
    MPC; Uncharacterized protein family (UPF0041)

  4. XM_063274001.1 → XP_063130071.1  mitochondrial pyruvate carrier 1 isoform X2

    UniProtKB/TrEMBL
    A6KK36
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63031.1 GenPept UniProtKB/Swiss-Prot:P63031

Gene LinkOut

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