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Lyz1 lysozyme 1 [ Mus musculus (house mouse) ]

Gene ID: 17110, updated on 5-Jan-2022

Summary

Official Symbol
Lyz1provided by MGI
Official Full Name
lysozyme 1provided by MGI
Primary source
MGI:MGI:96902
See related
Ensembl:ENSMUSG00000069515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lyz; Lyzf3; Lzp-s
Summary
Predicted to enable identical protein binding activity and lysozyme activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Predicted to be located in several cellular components, including Golgi cis cisterna; cytoplasmic vesicle; and rough endoplasmic reticulum lumen. Is expressed in embryo mesenchyme; liver and biliary system; and small intestine. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in large intestine adult (RPKM 3054.3), small intestine adult (RPKM 742.7) and 2 other tissues See more
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Genomic context

See Lyz1 in Genome Data Viewer
Location:
10; 10 D2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (117123700..117128773, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117287795..117292868, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (116724851..116729924, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530003J23 gene Neighboring gene lysozyme 2 Neighboring gene cleavage and polyadenylation specific factor 6 Neighboring gene predicted gene, 40770

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysozyme activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi cis cisterna ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lysozyme C-1
Names
1,4-beta-N-acetylmuramidase C
P lysozyme structural
lysozyme C type P
lysozyme f3
renal amyloidosis
NP_038618.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013590.4NP_038618.1  lysozyme C-1 precursor

    See identical proteins and their annotated locations for NP_038618.1

    Status: VALIDATED

    Source sequence(s)
    BC061129, CD742179
    Consensus CDS
    CCDS48695.1
    UniProtKB/Swiss-Prot
    P17897
    UniProtKB/TrEMBL
    A0A077S9N1
    Related
    ENSMUSP00000089800.6, ENSMUST00000092162.7
    Conserved Domains (1) summary
    smart00263
    Location:19147
    LYZ1; Alpha-lactalbumin / lysozyme C

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    117123700..117128773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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