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Tm4sf1 transmembrane 4 superfamily member 1 [ Mus musculus (house mouse) ]

Gene ID: 17112, updated on 21-Apr-2024

Summary

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Official Symbol
Tm4sf1provided by MGI
Official Full Name
transmembrane 4 superfamily member 1provided by MGI
Primary source
MGI:MGI:104678
See related
Ensembl:ENSMUSG00000027800 AllianceGenome:MGI:104678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L6; M3s1
Summary
Acts upstream of or within blastocyst formation. Predicted to be integral component of plasma membrane. Predicted to be integral component of membrane. Is expressed in cardiovascular system; early conceptus; floor plate; pancreas; and secondary oocyte. Orthologous to human TM4SF1 (transmembrane 4 L six family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 43.9), heart adult (RPKM 24.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 D; 3 27.68 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (57193038..57295150, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (57285611..57387736, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07726 Neighboring gene La ribonucleoprotein domain family, member 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07727 Neighboring gene proliferating cell nuclear antigen pseudogene Neighboring gene microRNA 12195 Neighboring gene STARR-seq mESC enhancer starr_07730 Neighboring gene STARR-seq mESC enhancer starr_07731 Neighboring gene aldolase A, fructose-bisphosphate pseudogene Neighboring gene predicted gene, 52659 Neighboring gene transmembrane 4 superfamily member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of the murine counterpart of the tumor-associated antigen H-L6: epitope mapping of the human and murine L6 antigens. Edwards CP, et al. Biochemistry, 1995 Oct 3. PMID 7548016
  2. TM4SF1: a new vascular therapeutic target in cancer. Lin CI, et al. Angiogenesis, 2014 Oct. PMID 24986520, Free PMC Article
  3. Tumor-associated antigen L6 and the invasion of human lung cancer cells. Kao YR, et al. Clin Cancer Res, 2003 Jul. PMID 12855661
  4. Molecular cloning of a cDNA for rat TM4SF4, a homolog of human il-TMP (TM4SF4), and enhanced expression of the corresponding gene in regenerating rat liver(1). Liu Z, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267677
  5. The cDNA cloning of the hamster homologue of the human L6 gene. Maruyama M, et al. Gene, 1996 Feb 12. PMID 8654959

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAL6 may play a role in cancer invasion and metastasis
    Title: Tumor-associated antigen L6 and the invasion of human lung cancer cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane 4 L6 family member 1
Names
12A8 target antigen
L6 antigen
membrane component chromosome 3 surface marker 1 homolog
membrane component, surface marker 1
tumor-associated antigen L6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355130.2 → NP_001342059.1  transmembrane 4 L6 family member 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC119854
    Consensus CDS
    CCDS38433.1
    UniProtKB/Swiss-Prot
    Q3TP49, Q64302
    UniProtKB/TrEMBL
    Q3UZY2
    Related
    ENSMUSP00000029376.9, ENSMUST00000029376.13
    Conserved Domains (1) summary
    pfam05805
    Location:1 → 194
    L6_membrane; L6 membrane protein

  2. NM_001410064.1 → NP_001396993.1  transmembrane 4 L6 family member 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC119854
    UniProtKB/Swiss-Prot
    Q3TP49, Q64302
    Related
    ENSMUSP00000130999.2, ENSMUST00000171384.8

  3. NM_001410065.1 → NP_001396994.1  transmembrane 4 L6 family member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119854

  4. NM_001410066.1 → NP_001396995.1  transmembrane 4 L6 family member 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119854

  5. NM_001410067.1 → NP_001396996.1  transmembrane 4 L6 family member 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119854

  6. NM_001410068.1 → NP_001396997.1  transmembrane 4 L6 family member 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119854

  7. NM_008536.5 → NP_032562.1  transmembrane 4 L6 family member 1 isoform 1

    See identical proteins and their annotated locations for NP_032562.1

    Status: VALIDATED

    Source sequence(s)
    AC119854
    Consensus CDS
    CCDS38433.1
    UniProtKB/Swiss-Prot
    Q3TP49, Q64302
    UniProtKB/TrEMBL
    Q3UZY2
    Related
    ENSMUSP00000143652.2, ENSMUST00000196979.5
    Conserved Domains (1) summary
    pfam05805
    Location:1 → 194
    L6_membrane; L6 membrane protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    57193038..57295150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252446.1 → XP_030108306.1  transmembrane 4 L6 family member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TP49, Q64302
    UniProtKB/TrEMBL
    Q3UZY2
    Conserved Domains (1) summary
    pfam05805
    Location:1 → 194
    L6_membrane; L6 membrane protein

  2. XM_030252445.2 → XP_030108305.1  transmembrane 4 L6 family member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TP49, Q64302
    UniProtKB/TrEMBL
    Q3UZY2
    Conserved Domains (1) summary
    pfam05805
    Location:1 → 194
    L6_membrane; L6 membrane protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64302.1 GenPept UniProtKB/Swiss-Prot:Q64302

Gene LinkOut

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